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    Nr2f6 nuclear receptor subfamily 2, group F, member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245980, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nr2f6provided by RGD
    Official Full Name
    nuclear receptor subfamily 2, group F, member 6provided by RGD
    Primary source
    RGD:621685
    See related
    EnsemblRapid:ENSRNOG00000016892 AllianceGenome:RGD:621685
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleus. Orthologous to human NR2F6 (nuclear receptor subfamily 2 group F member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 310.8), Liver (RPKM 195.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nr2f6 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18080003..18087449, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18046012..18053914, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19769968..19777414, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene unconventional SNARE in the ER 1 Neighboring gene occludin/ELL domain containing 1 Neighboring gene USH1 protein network component harmonin binding protein 1 Neighboring gene uncharacterized LOC134482465 Neighboring gene BRISC and BRCA1 A complex member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in detection of temperature stimulus involved in sensory perception of pain  
    acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain  
    involved_in entrainment of circadian clock by photoperiod  
    acts_upstream_of_or_within entrainment of circadian clock by photoperiod  
    involved_in intracellular receptor signaling pathway  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in nervous system development  
    involved_in neuron development  
    acts_upstream_of_or_within neuron development  
    Component Evidence Code Pubs
    located_in mitochondrion PubMed 
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    nuclear receptor subfamily 2 group F member 6
    Names
    COUPg
    EAR-2
    V-erbA-related protein 2
    V-erbA-related protein EAR-2
    orphan nuclear receptor EAR-2
    ovalbumin upstream promoter gamma nuclear receptor rCOUPg

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139113.2NP_620813.2  nuclear receptor subfamily 2 group F member 6

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      O09017
      UniProtKB/TrEMBL
      F1LP04
      Related
      ENSRNOP00000022898.2, ENSRNOT00000022898.5
      Conserved Domains (2) summary
      cd06948
      Location:157387
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
      cd06958
      Location:57129
      NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18080003..18087449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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