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    Rassf2 Ras association domain family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rassf2provided by RGD
    Official Full Name
    Ras association domain family member 2provided by RGD
    Primary source
    RGD:1305551
    See related
    EnsemblRapid:ENSRNOG00000021261 AllianceGenome:RGD:1305551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in protein stabilization; regulation of intracellular signal transduction; and signal transduction. Predicted to act upstream of or within several processes, including canonical NF-kappaB signal transduction; negative regulation of non-canonical NF-kappaB signal transduction; and regulation of protein phosphorylation. Predicted to be located in several cellular components, including Golgi apparatus; kinetochore; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RASSF2 (Ras association domain family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 145.9), Thymus (RPKM 119.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rassf2 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (139697187..139733402, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (119244288..119280462, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (124574088..124610267, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486157 Neighboring gene prion protein Neighboring gene prion like protein doppel Neighboring gene uncharacterized LOC134486447 Neighboring gene uncharacterized LOC102552722 Neighboring gene solute carrier family 23 member 2 Neighboring gene choline/ethanolamine kinase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. Cooper WN, et al. Oncogene, 2009 Aug 20. PMID 19525978, Free PMC Article
    2. Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. Song H, et al. EMBO J, 2012 Mar 7. PMID 22227519, Free PMC Article
    3. Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Song H, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19962960
    4. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124713

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 2
    Names
    Ras association (RalGDS/AF-6) domain family 2
    Ras association (RalGDS/AF-6) domain family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037096.2 → NP_001032173.2  ras association domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q3B7D5
      UniProtKB/TrEMBL
      A6HQF2, G3V8W1
      Related
      ENSRNOP00000028883.7, ENSRNOT00000028883.9
      Conserved Domains (2) summary
      cd17221
      Location:177 → 263
      RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
      pfam16517
      Location:278 → 316
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      139697187..139733402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283783.1 → XP_063139853.1  ras association domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3B7D5
      UniProtKB/TrEMBL
      A6HQF2, G3V8W1

    2. XM_006235066.4 → XP_006235128.1  ras association domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006235128.1

      UniProtKB/Swiss-Prot
      Q3B7D5
      UniProtKB/TrEMBL
      A6HQF2, G3V8W1
      Conserved Domains (2) summary
      cd17221
      Location:177 → 263
      RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
      pfam16517
      Location:278 → 316
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    RNA

    1. XR_005501884.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B7D5.1 GenPept UniProtKB/Swiss-Prot:Q3B7D5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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