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    Zfp143 zinc finger protein 143 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361627, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfp143provided by RGD
    Official Full Name
    zinc finger protein 143provided by RGD
    Primary source
    RGD:1305662
    See related
    EnsemblRapid:ENSRNOG00000010087 AllianceGenome:RGD:1305662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    STAF; Znf143
    Summary
    Enables chromatin binding activity. Involved in positive regulation of smooth muscle cell proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 49.5), Spleen (RPKM 41.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Zfp143 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (173543810..173579667)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164109041..164144902)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174702310..174738133)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NHP2 ribonucleoprotein, pseudogene 5 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC134483773 Neighboring gene RNA, U6 small nuclear 1168 Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene switching B-cell complex subunit SWAP70

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in nucleus  

    General protein information

    Preferred Names
    zinc finger protein 143
    Names
    selenocysteine tRNA gene transcription-activating factor
    zfp-143
    NP_001012169.2
    XP_006230056.1
    XP_038938655.1
    XP_063123513.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012169.3NP_001012169.2  zinc finger protein 143

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5XIU2
      UniProtKB/TrEMBL
      A0A0H2UHI0, A6I808
      Related
      ENSRNOP00000013733.9, ENSRNOT00000013733.7
      Conserved Domains (3) summary
      COG5048
      Location:251424
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      173543810..173579667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229994.3XP_006230056.1  zinc finger protein 143 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHI0
      Conserved Domains (3) summary
      sd00017
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:312339
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:298413
      zf-C2H2_8; C2H2-type zinc ribbon
    2. XM_039082727.2XP_038938655.1  zinc finger protein 143 isoform X2

      UniProtKB/Swiss-Prot
      Q5XIU2
      UniProtKB/TrEMBL
      A0A0H2UHI0, A6I808
      Related
      ENSRNOP00000109958.1, ENSRNOT00000140259.1
      Conserved Domains (3) summary
      COG5048
      Location:251424
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_063267443.1XP_063123513.1  zinc finger protein 143 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHI0
      Related
      ENSRNOP00000077653.1, ENSRNOT00000119146.2
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