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    Haghl hydroxyacylglutathione hydrolase-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302995, updated on 9-Dec-2024

    Summary

    Official Symbol
    Haghlprovided by RGD
    Official Full Name
    hydroxyacylglutathione hydrolase-likeprovided by RGD
    Primary source
    RGD:1308042
    See related
    EnsemblRapid:ENSRNOG00000019612 AllianceGenome:RGD:1308042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hydroxyacylglutathione hydrolase activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Orthologous to human HAGHL (hydroxyacylglutathione hydrolase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 48.7), Thymus (RPKM 22.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Haghl in Genome Data Viewer
    Location:
    10q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15309469..15313910, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14804957..14809495, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15152736..15157221, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mesothelin Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene coiled-coil domain containing 78 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    hydroxyacylglutathione hydrolase-like protein
    XP_006246126.1
    XP_006246127.1
    XP_038943040.1
    XP_063126164.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430179.1NP_001417108.1  hydroxyacylglutathione hydrolase-like protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A2F7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15309469..15313910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246064.5XP_006246126.1  hydroxyacylglutathione hydrolase-like protein isoform X1

      See identical proteins and their annotated locations for XP_006246126.1

      Conserved Domains (1) summary
      PLN02469
      Location:1272
      PLN02469; hydroxyacylglutathione hydrolase
    2. XM_039087112.2XP_038943040.1  hydroxyacylglutathione hydrolase-like protein isoform X1

      Related
      ENSRNOP00000105397.1, ENSRNOT00000170473.1
      Conserved Domains (1) summary
      PLN02469
      Location:1272
      PLN02469; hydroxyacylglutathione hydrolase
    3. XM_063270094.1XP_063126164.1  hydroxyacylglutathione hydrolase-like protein isoform X2

      Related
      ENSRNOP00000026536.6, ENSRNOT00000026536.8
    4. XM_006246065.3XP_006246127.1  hydroxyacylglutathione hydrolase-like protein isoform X3

      Conserved Domains (2) summary
      pfam16123
      Location:126204
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cl23716
      Location:2125
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013114.1: Suppressed sequence

      Description
      NM_001013114.1: This RefSeq was temporarily suppressed because the CDS was partial and based on aberrant transcript data.