U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Ntrk2 neurotrophic receptor tyrosine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25054, updated on 7-Jan-2025

    Summary

    Official Symbol
    Ntrk2provided by RGD
    Official Full Name
    neurotrophic receptor tyrosine kinase 2provided by RGD
    Primary source
    RGD:3213
    See related
    EnsemblRapid:ENSRNOG00000018839 AllianceGenome:RGD:3213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tkrb; trkB; TRKB1; trk-B; RATTRKB1
    Summary
    Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including dendritic spine; distal axon; and perikaryon. Is active in glutamatergic synapse; postsynaptic membrane; and presynapse. Used to study glaucoma. Biomarker of several diseases, including alcohol use disorder; anxiety disorder (multiple); attention deficit hyperactivity disorder; borna disease; and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autistic disorder; developmental and epileptic encephalopathy 58; heroin dependence; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 177.9), Spleen (RPKM 47.3) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ntrk2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (5560558..5875899, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (5558992..5870299, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (5934651..6245778, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482764 Neighboring gene uncharacterized LOC120097867 Neighboring gene uncharacterized LOC120097773 Neighboring gene uncharacterized LOC134482662 Neighboring gene uncharacterized LOC120097777 Neighboring gene uncharacterized LOC120097774 Neighboring gene uncharacterized LOC102548918 Neighboring gene uncharacterized LOC108353117 Neighboring gene uncharacterized LOC120097776 Neighboring gene uncharacterized LOC134482803 Neighboring gene uncharacterized LOC134482663

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 42
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor binding  
    enables brain-derived neurotrophic factor binding PubMed 
    enables brain-derived neurotrophic factor binding  
    enables brain-derived neurotrophic factor binding PubMed 
    enables brain-derived neurotrophic factor binding  
    enables brain-derived neurotrophic factor receptor activity  
    enables brain-derived neurotrophic factor receptor activity PubMed 
    enables brain-derived neurotrophic factor receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables neurotrophin binding PubMed 
    enables neurotrophin binding  
    enables neurotrophin binding  
    enables neurotrophin receptor activity PubMed 
    enables neurotrophin receptor activity  
    enables neurotrophin receptor activity PubMed 
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protease binding  
    enables protease binding  
    enables protein binding PubMed 
    enables protein homodimerization activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables receptor tyrosine kinase binding PubMed 
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein serine/threonine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity PubMed 
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 42
    Items 1 - 25 of 104
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in brain-derived neurotrophic factor receptor signaling pathway PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in brain-derived neurotrophic factor receptor signaling pathway PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cellular response to amino acid stimulus  
    acts_upstream_of_or_within cellular response to amino acid stimulus  
    involved_in cellular response to brain-derived neurotrophic factor stimulus  
    involved_in cellular response to brain-derived neurotrophic factor stimulus PubMed 
    involved_in cellular response to nerve growth factor stimulus PubMed 
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in central nervous system neuron development  
    involved_in central nervous system neuron development  
    involved_in central nervous system neuron development  
    involved_in cerebral cortex development  
    involved_in cerebral cortex development  
    involved_in cerebral cortex development  
    involved_in chromatin remodeling  
    involved_in circadian rhythm  
    involved_in circadian rhythm  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in feeding behavior  
    acts_upstream_of_or_within feeding behavior  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in glutamate secretion  
    acts_upstream_of_or_within glutamate secretion  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in learning  
    involved_in learning  
    involved_in learning  
    involved_in long-term memory PubMed 
    involved_in long-term synaptic potentiation  
    involved_in long-term synaptic potentiation  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in mechanoreceptor differentiation  
    acts_upstream_of_or_within mechanoreceptor differentiation  
    involved_in multicellular organism development  
    involved_in myelination in peripheral nervous system  
    acts_upstream_of_or_within myelination in peripheral nervous system  
    involved_in negative regulation of amyloid-beta formation  
    acts_upstream_of_or_within negative regulation of amyloid-beta formation  
    involved_in negative regulation of anoikis  
    involved_in negative regulation of anoikis  
    involved_in negative regulation of neuron apoptotic process PubMed 
    involved_in neuron differentiation  
    involved_in neuron differentiation  
    involved_in neuron migration  
    involved_in neuron migration  
    involved_in neuron migration  
    involved_in neuronal action potential propagation  
    acts_upstream_of_or_within neuronal action potential propagation  
    involved_in neurotrophin signaling pathway  
    involved_in oligodendrocyte differentiation  
    involved_in oligodendrocyte differentiation  
    acts_upstream_of peptidyl-serine phosphorylation  
    involved_in peripheral nervous system neuron development  
    involved_in peripheral nervous system neuron development  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of axonogenesis PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of glucocorticoid receptor signaling pathway PubMed 
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development  
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of synapse assembly  
    acts_upstream_of_or_within positive regulation of synapse assembly  
    involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
    involved_in protein autophosphorylation PubMed 
    involved_in protein autophosphorylation PubMed 
    involved_in regulation of MAPK cascade PubMed 
    involved_in regulation of dendrite development PubMed 
    acts_upstream_of_or_within regulation of metabolic process  
    involved_in regulation of neurotransmitter secretion PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in response to auditory stimulus PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to light stimulus PubMed 
    acts_upstream_of_or_within retina development in camera-type eye  
    involved_in retinal rod cell development  
    acts_upstream_of_or_within retinal rod cell development  
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission  
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission  
    involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in vasculogenesis  
    acts_upstream_of_or_within vasculogenesis  
    Items 1 - 25 of 104
    Items 1 - 20 of 41
    Component Evidence Code Pubs
    located_in Golgi membrane  
    is_active_in axon  
    located_in axon PubMed 
    is_active_in axon terminus  
    located_in axon terminus PubMed 
    located_in cell surface PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    is_active_in dendritic spine  
    located_in dendritic spine PubMed 
    located_in early endosome  
    located_in early endosome  
    located_in early endosome  
    located_in early endosome membrane  
    located_in endosome  
    located_in excitatory synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in growth cone PubMed 
    located_in neuronal cell body PubMed 
    located_in perikaryon PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse PubMed 
    is_active_in postsynapse PubMed 
    is_active_in postsynaptic density  
    located_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynapse PubMed 
    located_in presynaptic active zone PubMed 
    part_of receptor complex  
    part_of receptor complex  
    part_of receptor complex  
    located_in terminal bouton  
    located_in terminal bouton  
    Items 1 - 20 of 41

    General protein information

    Preferred Names
    BDNF/NT-3 growth factors receptor
    Names
    GP145-TrkB/GP95-TrkB
    neural receptor protein-tyrosine kinase (trkB)
    neurotrophic tyrosine kinase, receptor, type 2
    neurotrophic tyrosine receptor kinase type 2
    trkB tyrosine kinase
    NP_001156640.1
    NP_036863.1
    XP_006253569.1
    XP_008769647.1
    XP_008769648.1
    XP_008769649.1
    XP_017455945.1
    XP_038951298.1
    XP_063132139.1
    XP_063132140.1
    XP_063132141.1
    XP_063132142.1
    XP_063132143.1
    XP_063132144.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163168.3NP_001156640.1  BDNF/NT-3 growth factors receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001156640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple coding exons and uses a distinct terminal exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to to isoform 1.
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I5ZVM2, A6KAJ1
      Related
      ENSRNOP00000070128.1, ENSRNOT00000090914.3
      Conserved Domains (7) summary
      smart00013
      Location:3164
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:205209
      Ig; Ig strand A' [structural motif]
      cd05855
      Location:286379
      IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    2. NM_012731.3NP_036863.1  BDNF/NT-3 growth factors receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_036863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q63604, Q63605, Q63606
      Related
      ENSRNOP00000045635.1, ENSRNOT00000042145.4
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      cd05093
      Location:531818
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:537806
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      5560558..5875899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276070.1XP_063132140.1  BDNF/NT-3 growth factors receptor isoform X2

      UniProtKB/Swiss-Prot
      Q63604, Q63605, Q63606
    2. XM_017600456.3XP_017455945.1  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5X6
      Conserved Domains (6) summary
      cd05093
      Location:547834
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:205209
      Ig; Ig strand A' [structural motif]
      cd05855
      Location:286379
      IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    3. XM_063276069.1XP_063132139.1  BDNF/NT-3 growth factors receptor isoform X2

      UniProtKB/Swiss-Prot
      Q63604, Q63605, Q63606
    4. XM_008771426.4XP_008769648.1  BDNF/NT-3 growth factors receptor isoform X1

      See identical proteins and their annotated locations for XP_008769648.1

      UniProtKB/TrEMBL
      A0A0G2K5X6
      Conserved Domains (6) summary
      cd05093
      Location:547834
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:205209
      Ig; Ig strand A' [structural motif]
      cd05855
      Location:286379
      IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    5. XM_039095370.2XP_038951298.1  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5X6
      Conserved Domains (6) summary
      cd05093
      Location:547834
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:205209
      Ig; Ig strand A' [structural motif]
      cd05855
      Location:286379
      IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    6. XM_008771425.4XP_008769647.1  BDNF/NT-3 growth factors receptor isoform X1

      See identical proteins and their annotated locations for XP_008769647.1

      UniProtKB/TrEMBL
      A0A0G2K5X6
      Related
      ENSRNOP00000073595.1, ENSRNOT00000082611.3
      Conserved Domains (6) summary
      cd05093
      Location:547834
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:205209
      Ig; Ig strand A' [structural motif]
      cd05855
      Location:286379
      IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    7. XM_063276071.1XP_063132141.1  BDNF/NT-3 growth factors receptor isoform X3

    8. XM_008771427.4XP_008769649.1  BDNF/NT-3 growth factors receptor isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZVM2
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00013
      Location:3164
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    9. XM_006253507.5XP_006253569.1  BDNF/NT-3 growth factors receptor isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZVM2
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00013
      Location:3164
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    10. XM_063276072.1XP_063132142.1  BDNF/NT-3 growth factors receptor isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZVM2, A6KAJ1
    11. XM_063276073.1XP_063132143.1  BDNF/NT-3 growth factors receptor isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZVM2, A6KAJ1
    12. XM_063276074.1XP_063132144.1  BDNF/NT-3 growth factors receptor isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZVM2, A6KAJ1

    External link. Please review our privacy policy.