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    Septin3 septin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56003, updated on 9-Dec-2024

    Summary

    Official Symbol
    Septin3provided by RGD
    Official Full Name
    septin 3provided by RGD
    Primary source
    RGD:621745
    See related
    EnsemblRapid:ENSRNOG00000007686 AllianceGenome:RGD:621745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sep3; Sept3
    Summary
    Enables GTP binding activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein catabolic process at presynapse; and protein localization. Located in presynaptic membrane. Is active in presynapse. Orthologous to human SEPTIN3 (septin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 296.4) and Testes (RPKM 25.4) See more
    Orthologs
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    Genomic context

    See Septin3 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115659414..115691173)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113783217..113811089)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123506535..123526542)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene centromere protein M Neighboring gene uncharacterized LOC108351520 Neighboring gene small integral membrane protein 45 Neighboring gene WBP2 N-terminal like Neighboring gene alpha-N-acetylgalactosaminidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding PubMed 
    enables GTP binding  
    enables GTPase activity  
    enables identical protein binding  
    enables molecular adaptor activity  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis  
    involved_in protein catabolic process at presynapse  
    involved_in protein localization  
    Component Evidence Code Pubs
    is_active_in cell division site  
    located_in cytoplasm  
    located_in cytoskeleton  
    is_active_in microtubule cytoskeleton  
    is_active_in presynapse PubMed 
    is_active_in presynapse  
    located_in presynapse  
    is_active_in presynaptic cytoskeleton  
    located_in presynaptic membrane PubMed 
    part_of septin complex  
    part_of septin complex  
    part_of septin complex  
    is_active_in septin ring  

    General protein information

    Preferred Names
    neuronal-specific septin-3
    Names
    G-septin alpha
    P40

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019375.2NP_062248.2  neuronal-specific septin-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9R245, Q9WU34, Q9WU35
      UniProtKB/TrEMBL
      A0A8I6A6E2, A6HT54
      Conserved Domains (1) summary
      cd01850
      Location:59333
      CDC_Septin; CDC/Septin GTPase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115659414..115691173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264164.1XP_063120234.1  neuronal-specific septin-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZX16, A0A8I6AME4
      Related
      ENSRNOP00000094557.1, ENSRNOT00000108676.2
    2. XM_063264163.1XP_063120233.1  neuronal-specific septin-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZX16, A0A8I6AME4
    3. XM_039079788.2XP_038935716.1  neuronal-specific septin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX16, A0A8I6G9D9
      Related
      ENSRNOP00000083723.1, ENSRNOT00000104827.2
      Conserved Domains (1) summary
      cd01850
      Location:540814
      CDC_Septin; CDC/Septin GTPase family
    4. XM_039079790.2XP_038935718.1  neuronal-specific septin-3 isoform X3

      UniProtKB/TrEMBL
      A6HT56, F1LMH0
      Related
      ENSRNOP00000010491.6, ENSRNOT00000010491.8
      Conserved Domains (1) summary
      cd01850
      Location:46320
      CDC_Septin; CDC/Septin GTPase family
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