Ermn ermin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ermnprovided by RGD
Official Full Name: erminprovided by RGD
Primary source: RGD:1308367
See related: EnsemblRapid:ENSRNOG00000021472 AllianceGenome:RGD:1308367
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308367; juxtanodin
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including actin filament organization; morphogenesis of a branching structure; and regulation of cell shape. Predicted to be located in cytoplasm and glial cell projection. Predicted to be active in several cellular components, including filopodium; main axon; and neuronal cell body. Orthologous to human ERMN (ermin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 429.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (63037001..63042657, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (42628160..42633816, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (44080350..44086006, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that juxtanodin is non-globular and monomeric in solution.
Title: Juxtanodin is an intrinsically disordered F-actin-binding protein.
Nkx2.2 is one of the essential transcription factors delivering the specificity of JN promoter in oligodendrocytes.
Title: Identification of Juxtanodin promoter and its transcriptional regulation during the ATRA-induced differentiation of C6 cells.
Specific phosphorylation of JN might serve as an important mechanism regulating JN functions.
Title: Dephosphorylation-dependent inhibitory activity of juxtanodin on filamentous actin disassembly.
These results identify JN as a marker protein for OE sustentacular cells, and support the glia-like nature of OE sustentacular cells.
Title: Juxtanodin in the rat olfactory epithelium: specific expression in sustentacular cells and preferential subcellular positioning at the apical junctional belt.
Juxtanodin is an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking.
Title: Juxtanodin: an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of a branching structure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within morphogenesis of a branching structure	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell projection organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
is_active_in internode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in internode region of axon	ISO Inferred from Sequence Orthology more info
is_active_in myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in paranode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ermin

Names: JN; ermin, ERM-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.