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    Fzd3 frizzled class receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266715, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fzd3provided by RGD
    Official Full Name
    frizzled class receptor 3provided by RGD
    Primary source
    RGD:628814
    See related
    EnsemblRapid:ENSRNOG00000047211 AllianceGenome:RGD:628814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Involved in response to electrical stimulus and response to xenobiotic stimulus. Predicted to be located in several cellular components, including apical plasma membrane; filopodium tip; and lateral plasma membrane. Predicted to be active in glutamatergic synapse and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (frizzled class receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 219.1), Kidney (RPKM 61.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Fzd3 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (43596962..43664047, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39421366..39488369, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48601259..48670257, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 9 Neighboring gene exostosin-like glycosyltransferase 3 Neighboring gene uncharacterized LOC134482133 Neighboring gene H/ACA ribonucleoprotein complex subunit 3-like Neighboring gene F-box protein 16 Neighboring gene uncharacterized LOC120097019

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables PDZ domain binding  
    enables Wnt receptor activity  
    enables Wnt receptor activity  
    enables Wnt-protein binding  
    enables Wnt-protein binding  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in Wnt signaling pathway, planar cell polarity pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of_or_within cell proliferation in midbrain  
    acts_upstream_of_or_within commissural neuron axon guidance  
    involved_in dopaminergic neuron axon guidance  
    acts_upstream_of_or_within establishment of planar polarity  
    involved_in hair follicle development  
    acts_upstream_of_or_within inner ear morphogenesis  
    acts_upstream_of_or_within midbrain development  
    acts_upstream_of_or_within motor neuron migration  
    involved_in negative regulation of execution phase of apoptosis  
    involved_in negative regulation of mitotic cell cycle, embryonic  
    acts_upstream_of_or_within neural tube closure  
    involved_in non-canonical Wnt signaling pathway  
    involved_in positive regulation of neuroblast proliferation  
    acts_upstream_of_or_within post-anal tail morphogenesis  
    involved_in response to electrical stimulus PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in serotonergic neuron axon guidance  
    involved_in sympathetic ganglion development  
    Component Evidence Code Pubs
    located_in apical part of cell  
    located_in apical plasma membrane  
    located_in axon  
    located_in cytoplasm  
    located_in dendrite  
    located_in filopodium tip  
    is_active_in glutamatergic synapse  
    located_in lateral plasma membrane  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in presynaptic active zone  
    is_active_in presynaptic active zone membrane  

    General protein information

    Preferred Names
    frizzled-3
    Names
    frizzled family receptor 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153474.2NP_703204.2  frizzled-3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6J1, Q8CJC4
      Related
      ENSRNOP00000067360.3, ENSRNOT00000071464.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      43596962..43664047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274036.1XP_063130106.1  frizzled-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWZ3, M0RCN5
      Related
      ENSRNOP00000083631.1, ENSRNOT00000109699.2
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