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    Thoc2 THO complex subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313308, updated on 9-Dec-2024

    Summary

    Official Symbol
    Thoc2provided by RGD
    Official Full Name
    THO complex subunit 2provided by RGD
    Primary source
    RGD:1561623
    See related
    EnsemblRapid:ENSRNOG00000007315 AllianceGenome:RGD:1561623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561623
    Summary
    Predicted to enable mRNA binding activity. Involved in negative regulation of neuron projection development. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 231.8), Spleen (RPKM 153.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Thoc2 in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (125500549..125615139, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (120634966..120749569, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (128153824..128268327, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484131 Neighboring gene eukaryotic translation initiation factor 3, subunit K, pseudogene 2 Neighboring gene THO complex 2, pseudogene 1 Neighboring gene similar to 40S ribosomal protein S2 Neighboring gene X-linked inhibitor of apoptosis Neighboring gene STAG2 cohesin complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding  
    enables mRNA binding  
    Component Evidence Code Pubs
    part_of THO complex  
    part_of THO complex part of transcription export complex  
    part_of THO complex part of transcription export complex  
    located_in chromosome, telomeric region  
    located_in membrane  
    located_in nucleus  
    part_of transcription export complex  

    General protein information

    Preferred Names
    THO complex subunit 2
    Names
    THO complex 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191756.2NP_001178685.1  THO complex subunit 2

      See identical proteins and their annotated locations for NP_001178685.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F1M0V4
      Related
      ENSRNOP00000102762.1, ENSRNOT00000163986.1
      Conserved Domains (5) summary
      pfam11262
      Location:8741173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568642
      Thoc2; Transcription- and export-related complex subunit
      pfam12278
      Location:14481557
      SDP_N; Sex determination protein N terminal
      pfam12871
      Location:13471471
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16134
      Location:11566
      THOC2_N; THO complex subunit 2 N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      125500549..125615139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257504.5XP_006257566.1  THO complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8V3, F1M0V4
      Related
      ENSRNOP00000074749.2, ENSRNOT00000081880.3
      Conserved Domains (4) summary
      pfam11262
      Location:8741173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568642
      Thoc2; Transcription- and export-related complex subunit
      pfam12278
      Location:14751584
      SDP_N; Sex determination protein N terminal
      pfam16134
      Location:11566
      THOC2_N; THO complex subunit 2 N-terminus
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