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    Slc22a3 solute carrier family 22 member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29504, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc22a3provided by RGD
    Official Full Name
    solute carrier family 22 member 3provided by RGD
    Primary source
    RGD:3701
    See related
    EnsemblRapid:ENSRNOG00000022946 AllianceGenome:RGD:3701
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    EMT; OCT3
    Summary
    Enables several functions, including dopamine:sodium symporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including histamine transport; monoamine transport; and spermidine transport. Located in apical plasma membrane; endomembrane system; and mitochondrial membrane. Orthologous to human SLC22A3 (solute carrier family 22 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 72.3), Heart (RPKM 35.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Slc22a3 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50783218..50872358)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (48235476..48324617)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48433079..48521261)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 10 Neighboring gene uncharacterized LOC102553224 Neighboring gene plasminogen Neighboring gene deoxyuridine triphosphatase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dopamine:sodium symporter activity PubMed 
    enables monoamine transmembrane transporter activity PubMed 
    enables monoamine transmembrane transporter activity  
    enables neurotransmitter transmembrane transporter activity PubMed 
    enables neurotransmitter transmembrane transporter activity  
    enables organic anion transmembrane transporter activity PubMed 
    enables organic cation transmembrane transporter activity  
    enables organic cation transmembrane transporter activity PubMed 
    enables organic cation transmembrane transporter activity  
    enables protein binding PubMed 
    enables quaternary ammonium group transmembrane transporter activity PubMed 
    enables quaternary ammonium group transmembrane transporter activity  
    enables spermidine transmembrane transporter activity PubMed 
    enables toxin transmembrane transporter activity PubMed 
    enables toxin transmembrane transporter activity  
    enables transmembrane transporter activity  
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in cellular detoxification  
    involved_in dopamine transport PubMed 
    involved_in dopamine transport  
    involved_in dopamine uptake  
    involved_in epinephrine transport PubMed 
    involved_in epinephrine transport  
    involved_in epinephrine uptake  
    acts_upstream_of_or_within establishment of localization in cell  
    involved_in histamine transport PubMed 
    acts_upstream_of_or_within histamine transport  
    involved_in histamine transport  
    acts_upstream_of_or_within histamine uptake  
    involved_in histamine uptake  
    acts_upstream_of_or_within monoamine transport  
    involved_in monoamine transport  
    involved_in monoatomic ion transport  
    acts_upstream_of_or_within monocarboxylic acid transport  
    acts_upstream_of_or_within neurotransmitter transport  
    involved_in neurotransmitter transport  
    involved_in norepinephrine transport PubMed 
    involved_in norepinephrine transport  
    involved_in norepinephrine uptake  
    involved_in organic anion transport PubMed 
    involved_in organic cation transport  
    involved_in organic cation transport PubMed 
    acts_upstream_of_or_within organic cation transport  
    involved_in organic cation transport  
    acts_upstream_of_or_within organic hydroxy compound transport  
    involved_in quaternary ammonium group transport PubMed 
    acts_upstream_of_or_within quaternary ammonium group transport  
    involved_in quaternary ammonium group transport  
    acts_upstream_of_or_within regulation of appetite  
    involved_in serotonin transport PubMed 
    involved_in serotonin transport  
    involved_in serotonin uptake  
    involved_in spermidine transmembrane transport  
    involved_in spermidine transport PubMed 
    involved_in xenobiotic transport  
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in endomembrane system PubMed 
    located_in endomembrane system  
    located_in mitochondrial membrane PubMed 
    located_in mitochondrial membrane  
    located_in neuronal cell body  
    located_in nuclear outer membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in presynapse  

    General protein information

    Preferred Names
    solute carrier family 22 member 3
    Names
    extraneuronal monoamine transporter
    organic cation transporter 3
    solute carrier family 22 (extraneuronal monoamine transporter), member 3
    solute carrier family 22 (organic cation transporter), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019230.1NP_062103.1  solute carrier family 22 member 3

      See identical proteins and their annotated locations for NP_062103.1

      Status: PROVISIONAL

      Source sequence(s)
      AF055286
      UniProtKB/Swiss-Prot
      O88446
      UniProtKB/TrEMBL
      A6KJX6
      Related
      ENSRNOP00000029748.2, ENSRNOT00000037369.4
      Conserved Domains (2) summary
      cd06174
      Location:145513
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12523
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      50783218..50872358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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