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    Elovl5 ELOVL fatty acid elongase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171400, updated on 9-Dec-2024

    Summary

    Official Symbol
    Elovl5provided by RGD
    Official Full Name
    ELOVL fatty acid elongase 5provided by RGD
    Primary source
    RGD:620583
    See related
    EnsemblRapid:ENSRNOG00000006331 AllianceGenome:RGD:620583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rELO1
    Summary
    Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid and very long-chain fatty acid biosynthetic process. Predicted to be located in dendritic tree; endoplasmic reticulum; and neuronal cell body. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 38. Orthologous to human ELOVL5 (ELOVL fatty acid elongase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1343.4), Adrenal (RPKM 525.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Elovl5 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (87671164..87737618)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (78790846..78857307)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85220941..85287449)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene glutamate-cysteine ligase, catalytic subunit Neighboring gene uncharacterized LOC134480076 Neighboring gene uncharacterized LOC134480077 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acid elongase activity  
    enables fatty acid elongase activity PubMed 
    enables fatty acid elongase activity  
    enables fatty acid elongase activity  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process  
    involved_in fatty acid elongation, monounsaturated fatty acid  
    involved_in fatty acid elongation, monounsaturated fatty acid  
    involved_in fatty acid elongation, monounsaturated fatty acid  
    involved_in fatty acid elongation, monounsaturated fatty acid  
    involved_in fatty acid elongation, polyunsaturated fatty acid  
    involved_in fatty acid elongation, polyunsaturated fatty acid PubMed 
    involved_in fatty acid elongation, polyunsaturated fatty acid  
    involved_in fatty acid elongation, polyunsaturated fatty acid  
    involved_in fatty acid elongation, saturated fatty acid  
    involved_in fatty acid elongation, saturated fatty acid  
    involved_in long-chain fatty-acyl-CoA biosynthetic process  
    involved_in positive regulation of fatty acid biosynthetic process  
    involved_in positive regulation of fatty acid biosynthetic process  
    involved_in sphingolipid biosynthetic process  
    involved_in unsaturated fatty acid biosynthetic process  
    involved_in very long-chain fatty acid biosynthetic process  
    involved_in very long-chain fatty acid biosynthetic process PubMed 
    involved_in very long-chain fatty acid biosynthetic process  
    involved_in very long-chain fatty acid biosynthetic process  
    Component Evidence Code Pubs
    located_in dendrite  
    located_in dendritic tree  
    located_in dendritic tree  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in neuronal cell body  

    General protein information

    Preferred Names
    very long chain fatty acid elongase 5
    Names
    3-keto acyl-CoA synthase Elovl5
    ELOVL FA elongase 5
    ELOVL family member 5, elongation of long chain fatty acids
    elongation of long chain fatty acids family member 5
    elongation of very long chain fatty acids protein 5
    elongation of very long chain fatty acids-like 5
    fatty acid elongase 1
    very long chain 3-ketoacyl-CoA synthase 5
    very long chain 3-oxoacyl-CoA synthase 5
    NP_599209.1
    XP_063120907.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134382.2NP_599209.1  very long chain fatty acid elongase 5

      See identical proteins and their annotated locations for NP_599209.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      G9BD46, Q920L7
      UniProtKB/TrEMBL
      A0A8I6AI17
      Conserved Domains (1) summary
      pfam01151
      Location:27261
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      87671164..87737618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264837.1XP_063120907.1  very long chain fatty acid elongase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI17
      Related
      ENSRNOP00000010409.4, ENSRNOT00000010409.6
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