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    Dhps deoxyhypusine synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288923, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dhpsprovided by RGD
    Official Full Name
    deoxyhypusine synthaseprovided by RGD
    Primary source
    RGD:1303326
    See related
    EnsemblRapid:ENSRNOG00000004219 AllianceGenome:RGD:1303326
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables deoxyhypusine synthase activity and identical protein binding activity. Involved in spermidine catabolic process. Predicted to be active in cytoplasm. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 195.8), Muscle (RPKM 182.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dhps in Genome Data Viewer
    Location:
    19q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (39987328..39991418, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23082454..23086544, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26184665..26188755)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 2B, member 1 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene WD repeat domain 83 Neighboring gene G protein subunit gamma 14 Neighboring gene F-box and WD repeat domain containing 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC94237

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deoxyhypusine synthase activity  
    enables deoxyhypusine synthase activity PubMed 
    enables deoxyhypusine synthase activity  
    enables identical protein binding PubMed 
    enables identical protein binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol  

    General protein information

    Preferred Names
    deoxyhypusine synthase
    Names
    DHS
    NP_001004207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004207.1NP_001004207.1  deoxyhypusine synthase

      See identical proteins and their annotated locations for NP_001004207.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079188
      UniProtKB/Swiss-Prot
      Q6AY53
      UniProtKB/TrEMBL
      A6IY30
      Related
      ENSRNOP00000005656.3, ENSRNOT00000005656.7
      Conserved Domains (1) summary
      pfam01916
      Location:45351
      DS; Deoxyhypusine synthase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      39987328..39991418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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