U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Marchf1 membrane associated ring-CH-type finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361135, updated on 9-Dec-2024

    Summary

    Symbol
    Marchf1provided by RGD
    Full Name
    membrane associated ring-CH-type finger 1provided by RGD
    Primary source
    RGD:1305148
    See related
    EnsemblRapid:ENSRNOG00000026310 AllianceGenome:RGD:1305148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    March1; RGD1305148
    Summary
    Predicted to enable MHC protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class II; immune response; and protein polyubiquitination. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; lysosomal membrane; and trans-Golgi network membrane. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Orthologous to human MARCHF1 (membrane associated ring-CH-type finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 150.6), Thymus (RPKM 36.7) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Marchf1 in Genome Data Viewer
    Location:
    16p14-p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (28022159..28880872, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (23255551..24114290, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (24998709..25856327, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transketolase-like 2 Neighboring gene translation machinery associated 16 homolog Neighboring gene 60S ribosomal protein L22-like 1 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120097418 Neighboring gene BCL2 interacting protein 3, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, pseudogene 2 Neighboring gene uncharacterized LOC134482491 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC protein binding  
    enables MHC protein binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in cytoplasm  
    is_active_in early endosome membrane  
    located_in early endosome membrane  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endosome  
    located_in intracellular membrane-bounded organelle  
    is_active_in late endosome membrane  
    located_in late endosome membrane  
    located_in lysosomal membrane  
    is_active_in lysosome  
    located_in lysosome  
    located_in plasma membrane  
    located_in trans-Golgi network membrane  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MARCHF1
    Names
    E3 ubiquitin-protein ligase MARCH1
    E3 ubiquitin-protein ligase MARCH1-like
    membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
    NP_001129310.1
    NP_001388434.1
    XP_008769356.3
    XP_017455664.2
    XP_017455665.2
    XP_038950560.1
    XP_038950561.1
    XP_038950562.1
    XP_038950563.1
    XP_063131582.1
    XP_063131583.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135838.2 → NP_001129310.1  E3 ubiquitin-protein ligase MARCHF1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D4A6K8
      Related
      ENSRNOP00000102883.1, ENSRNOT00000148808.1
      Conserved Domains (1) summary
      cd16698
      Location:75 → 126
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    2. NM_001401505.1 → NP_001388434.1  E3 ubiquitin-protein ligase MARCHF1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Related
      ENSRNOP00000092175.2, ENSRNOT00000110592.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      28022159..28880872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600176.3 → XP_017455665.2  E3 ubiquitin-protein ligase MARCHF1 isoform X2

      Conserved Domains (1) summary
      cd16698
      Location:332 → 383
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    2. XM_039094632.2 → XP_038950560.1  E3 ubiquitin-protein ligase MARCHF1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH31
      Conserved Domains (1) summary
      cd16698
      Location:332 → 383
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    3. XM_039094634.2 → XP_038950562.1  E3 ubiquitin-protein ligase MARCHF1 isoform X3

      Conserved Domains (1) summary
      cd16698
      Location:328 → 379
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    4. XM_008771134.4 → XP_008769356.3  E3 ubiquitin-protein ligase MARCHF1 isoform X5

      Conserved Domains (1) summary
      cd16698
      Location:79 → 130
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    5. XM_039094635.2 → XP_038950563.1  E3 ubiquitin-protein ligase MARCHF1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AQF1
      Related
      ENSRNOP00000101945.1, ENSRNOT00000157784.1
      Conserved Domains (1) summary
      cd16698
      Location:79 → 130
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    6. XM_063275512.1 → XP_063131582.1  E3 ubiquitin-protein ligase MARCHF1 isoform X3

    7. XM_039094633.2 → XP_038950561.1  E3 ubiquitin-protein ligase MARCHF1 isoform X3

      Conserved Domains (1) summary
      cd16698
      Location:328 → 379
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    8. XM_017600175.3 → XP_017455664.2  E3 ubiquitin-protein ligase MARCHF1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH31
      Related
      ENSRNOP00000100848.1, ENSRNOT00000160934.1
      Conserved Domains (1) summary
      cd16698
      Location:332 → 383
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
    9. XM_063275513.1 → XP_063131583.1  E3 ubiquitin-protein ligase MARCHF1 isoform X6

      UniProtKB/TrEMBL
      A6KFM4
    External link. Please review our privacy policy.