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    Limd2 LIM domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Limd2provided by RGD
    Official Full Name
    LIM domain containing 2provided by RGD
    Primary source
    RGD:1309967
    See related
    AllianceGenome:RGD:1309967
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309967
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in actin cytoskeleton and plasma membrane. Orthologous to human LIMD2 (LIM domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 1041.6), Spleen (RPKM 605.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Limd2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91590079..91592747, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91090279..91092772, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94350789..94353301, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene translational activator of cytochrome c oxidase I Neighboring gene mitogen activated protein kinase kinase kinase 3 Neighboring gene STE20 related adaptor alpha Neighboring gene coiled-coil domain containing 47

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112915

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LIM domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025715.1 → NP_001020886.1  LIM domain-containing protein 2

      See identical proteins and their annotated locations for NP_001020886.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098855
      UniProtKB/Swiss-Prot
      Q4KM31
      UniProtKB/TrEMBL
      A0A8L2QH08, A6HK04
      Conserved Domains (1) summary
      cd09486
      Location:41 → 93
      LIM_Eplin_like_1; a LIM domain subfamily on a group of proteins with unknown function

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      91590079..91592747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247622.5 → XP_006247684.1  LIM domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006247684.1

      UniProtKB/Swiss-Prot
      Q4KM31
      UniProtKB/TrEMBL
      A0A8L2QH08, A6HK04
      Conserved Domains (1) summary
      cd09486
      Location:41 → 93
      LIM_Eplin_like_1; a LIM domain subfamily on a group of proteins with unknown function

    2. XM_006247621.5 → XP_006247683.1  LIM domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006247683.1

      UniProtKB/Swiss-Prot
      Q4KM31
      UniProtKB/TrEMBL
      A0A8L2QH08, A6HK04
      Conserved Domains (1) summary
      cd09486
      Location:41 → 93
      LIM_Eplin_like_1; a LIM domain subfamily on a group of proteins with unknown function

    3. XM_063269462.1 → XP_063125532.1  LIM domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q4KM31
      UniProtKB/TrEMBL
      A0A8L2QH08, A6HK04
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KM31.1 GenPept UniProtKB/Swiss-Prot:Q4KM31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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