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    Fmnl2 formin-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fmnl2provided by RGD
    Official Full Name
    formin-like 2provided by RGD
    Primary source
    RGD:1560248
    See related
    EnsemblRapid:ENSRNOG00000055567 AllianceGenome:RGD:1560248
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560248
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Is active in glutamatergic synapse and postsynapse. Orthologous to human FMNL2 (formin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 122.2), Brain (RPKM 114.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fmnl2 in Genome Data Viewer
    Location:
    3q12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (57758236..58033832)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (37348791..37624746)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (38400409..38677637)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A2, pseudogene 1 Neighboring gene developmental pluripotency associated 5A like 1 Neighboring gene uncharacterized LOC134486095 Neighboring gene uncharacterized LOC134486096 Neighboring gene pre-mRNA processing factor 40 homolog A Neighboring gene ARF like GTPase 6 interacting protein 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion. Chazeau A, et al. EMBO J, 2014 Dec 1. PMID 25293574, Free PMC Article
    2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formin-like 2; formin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      57758236..58033832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106785.2 → XP_038962713.1  formin-like protein 2 isoform X2

      Conserved Domains (3) summary
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:622 → 973
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. XM_039106787.2 → XP_038962715.1  formin-like protein 2 isoform X5

      Conserved Domains (3) summary
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:622 → 973
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. XM_039106784.2 → XP_038962712.1  formin-like protein 2 isoform X1

      Related
      ENSRNOP00000101642.1, ENSRNOT00000134952.1
      Conserved Domains (3) summary
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:622 → 973
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    4. XM_017592149.3 → XP_017447638.2  formin-like protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K132
      Related
      ENSRNOP00000071681.2, ENSRNOT00000085545.3
      Conserved Domains (3) summary
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:615 → 966
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    5. XM_008761823.4 → XP_008760045.2  formin-like protein 2 isoform X8

      Conserved Domains (3) summary
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:615 → 966
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    6. XM_008761822.4 → XP_008760044.2  formin-like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AKV5
      Conserved Domains (3) summary
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:615 → 966
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    7. XM_039106789.2 → XP_038962717.1  formin-like protein 2 isoform X9

      Conserved Domains (3) summary
      pfam06367
      Location:227 → 424
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:571 → 922
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 224
      Drf_GBD; Diaphanous GTPase-binding Domain

    8. XM_039106790.2 → XP_038962718.1  formin-like protein 2 isoform X10

      Conserved Domains (3) summary
      pfam06367
      Location:227 → 424
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:564 → 915
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 224
      Drf_GBD; Diaphanous GTPase-binding Domain

    9. XM_039106786.2 → XP_038962714.1  formin-like protein 2 isoform X3

      Conserved Domains (3) summary
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:622 → 973
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    10. XM_063284876.1 → XP_063140946.1  formin-like protein 2 isoform X3

    11. XM_039106788.2 → XP_038962716.1  formin-like protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AV50
      Related
      ENSRNOP00000098738.1, ENSRNOT00000129567.1
      Conserved Domains (3) summary
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:615 → 966
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein Strain
    Heading Accession and Version

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