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    Vrk1 VRK serine/threonine kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vrk1provided by RGD
    Official Full Name
    VRK serine/threonine kinase 1provided by RGD
    Primary source
    RGD:1306069
    See related
    EnsemblRapid:ENSRNOG00000005274 AllianceGenome:RGD:1306069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including histone binding activity; histone kinase activity; and nucleosomal DNA binding activity. Predicted to be involved in several processes, including Cajal body organization; Golgi disassembly; and positive regulation of protein localization to chromatin. Predicted to act upstream of or within protein autophosphorylation. Predicted to be located in several cellular components, including Golgi stack; chromatin; and nuclear lumen. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 248.1), Spleen (RPKM 157.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vrk1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (130679400..130746089)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (124914770..124981508)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (129835788..129902839)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103616 Neighboring gene uncharacterized LOC134479472 Neighboring gene uncharacterized LOC134479293 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activity. Shin J, et al. J Biol Chem, 2011 Jun 24. PMID 21543316, Free PMC Article
    2. Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation. López-Sánchez I, et al. Mol Cell Biol, 2009 Mar. PMID 19103756, Free PMC Article
    3. Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells. Kang TH, et al. Mol Cell Biol, 2007 Dec. PMID 17938195, Free PMC Article
    4. Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. Kim W, et al. J Biol Chem, 2012 Feb 17. PMID 22194607, Free PMC Article
    5. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols RJ, et al. J Biol Chem, 2004 Feb 27. PMID 14645249

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings collectively support a role of VRK1 as a novel mitotic histone H3 kinase in mammals.
      Title: Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AX kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3S10 kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3T3 kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosomal DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cajal body organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase VRK1
    Names
    vaccinia related kinase 1
    NP_001012194.1
    XP_006240592.1
    XP_006240593.1
    XP_006240594.1
    XP_038968462.1
    XP_038968463.1
    XP_038968464.1
    XP_038968465.1
    XP_038968466.1
    XP_038968468.1
    XP_038968469.1
    XP_038968471.1
    XP_063118199.1
    XP_063118200.1
    XP_063118201.1
    XP_063118202.1
    XP_063118203.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012194.2 → NP_001012194.1  serine/threonine-protein kinase VRK1 isoform 1

      See identical proteins and their annotated locations for NP_001012194.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2
      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    2. NM_001434016.1 → NP_001420945.1  serine/threonine-protein kinase VRK1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2

    3. NM_001434017.1 → NP_001420946.1  serine/threonine-protein kinase VRK1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2

    4. NM_001434018.1 → NP_001420947.1  serine/threonine-protein kinase VRK1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2

    5. NM_001434019.1 → NP_001420948.1  serine/threonine-protein kinase VRK1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2

    6. NM_001434020.1 → NP_001420949.1  serine/threonine-protein kinase VRK1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2

    7. NM_001434021.1 → NP_001420950.1  serine/threonine-protein kinase VRK1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2

    8. NM_001434022.1 → NP_001420951.1  serine/threonine-protein kinase VRK1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AIR3

    9. NM_001434023.1 → NP_001420952.1  serine/threonine-protein kinase VRK1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AIR3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      130679400..130746089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112534.2 → XP_038968462.1  serine/threonine-protein kinase VRK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2
      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    2. XM_006240532.5 → XP_006240594.1  serine/threonine-protein kinase VRK1 isoform X1

      See identical proteins and their annotated locations for XP_006240594.1

      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2
      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    3. XM_006240530.5 → XP_006240592.1  serine/threonine-protein kinase VRK1 isoform X1

      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    4. XM_039112543.2 → XP_038968471.1  serine/threonine-protein kinase VRK1 isoform X2

      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    5. XM_039112540.2 → XP_038968468.1  serine/threonine-protein kinase VRK1 isoform X1

      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    6. XM_063262131.1 → XP_063118201.1  serine/threonine-protein kinase VRK1 isoform X2

    7. XM_063262130.1 → XP_063118200.1  serine/threonine-protein kinase VRK1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIR3

    8. XM_006240531.5 → XP_006240593.1  serine/threonine-protein kinase VRK1 isoform X1

      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    9. XM_063262132.1 → XP_063118202.1  serine/threonine-protein kinase VRK1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIR3

    10. XM_039112538.2 → XP_038968466.1  serine/threonine-protein kinase VRK1 isoform X1

      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    11. XM_063262129.1 → XP_063118199.1  serine/threonine-protein kinase VRK1 isoform X1

      Related
      ENSRNOP00000029546.6, ENSRNOT00000036035.6

    12. XM_063262133.1 → XP_063118203.1  serine/threonine-protein kinase VRK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2

    13. XM_039112535.2 → XP_038968463.1  serine/threonine-protein kinase VRK1 isoform X1

      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    14. XM_039112536.2 → XP_038968464.1  serine/threonine-protein kinase VRK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2
      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    15. XM_039112537.2 → XP_038968465.1  serine/threonine-protein kinase VRK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2
      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    16. XM_039112541.2 → XP_038968469.1  serine/threonine-protein kinase VRK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIR3, Q6AYA2
      Conserved Domains (1) summary
      cd14122
      Location:26 → 326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    Nucleotide Protein Strain
    Heading Accession and Version

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