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    Zan zonadhesin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304379, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zanprovided by RGD
    Official Full Name
    zonadhesinprovided by RGD
    Primary source
    RGD:1305044
    See related
    EnsemblRapid:ENSRNOG00000067638 AllianceGenome:RGD:1305044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable extracellular matrix binding activity. Predicted to act upstream of or within binding activity of sperm to zona pellucida and regulation of binding activity of sperm to zona pellucida. Predicted to be located in plasma membrane. Orthologous to human ZAN (zonadhesin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 21.6), Adrenal (RPKM 16.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zan in Genome Data Viewer
    Location:
    12q12
    Exon count:
    91
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24851798..24963837)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19215018..19322789)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22285377..22389008)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene POP7 homolog, ribonuclease P/MRP subunit Neighboring gene erythropoietin Neighboring gene uncharacterized LOC134481172 Neighboring gene EPH receptor B4 Neighboring gene uncharacterized LOC103691283 Neighboring gene solute carrier family 12, member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida. Tardif S, et al. J Biol Chem, 2010 Aug 6. PMID 20529856, Free PMC Article
    2. A sperm membrane protein that binds in a species-specific manner to the egg extracellular matrix is homologous to von Willebrand factor. Hardy DM, et al. J Biol Chem, 1995 Nov 3. PMID 7592795

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zonadhesin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107134.3 → NP_001100604.2  zonadhesin precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      Related
      ENSRNOP00000094851.2, ENSRNOT00000098130.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      24851798..24963837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090053.2 → XP_038945981.1  zonadhesin isoform X2

      Conserved Domains (10) summary
      smart00832
      Location:2657 → 2728
      C8; This domain contains 8 conserved cysteine residues
      PRK10811
      Location:1117 → 1318
      rne; ribonuclease E; Reviewed
      pfam05109
      Location:472 → 834
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:4773 → 4827
      TILa; TILa domain
      cl17735
      Location:6008 → 6061
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:2461 → 2616
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:382 → 544
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:5953 → 6006
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:3067 → 3125
      C8; C8 domain
      cd19941
      Location:2345 → 2398
      TIL; trypsin inhibitor-like cysteine rich domain

    2. XM_039090057.2 → XP_038945985.1  zonadhesin isoform X7

      Conserved Domains (9) summary
      smart00832
      Location:2672 → 2743
      C8; This domain contains 8 conserved cysteine residues
      PRK10811
      Location:1132 → 1333
      rne; ribonuclease E; Reviewed
      pfam12714
      Location:3919 → 3973
      TILa; TILa domain
      cl17735
      Location:2802 → 2857
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:2476 → 2631
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:397 → 559
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:2746 → 2800
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:3082 → 3140
      C8; C8 domain
      cd19941
      Location:2360 → 2413
      TIL; trypsin inhibitor-like cysteine rich domain

    3. XM_063271286.1 → XP_063127356.1  zonadhesin isoform X8

    4. XM_039090052.2 → XP_038945980.1  zonadhesin isoform X1

      Conserved Domains (10) summary
      smart00832
      Location:2672 → 2743
      C8; This domain contains 8 conserved cysteine residues
      PRK10811
      Location:1132 → 1333
      rne; ribonuclease E; Reviewed
      pfam05109
      Location:487 → 849
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:4788 → 4842
      TILa; TILa domain
      cl17735
      Location:6023 → 6076
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:2476 → 2631
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:397 → 559
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:5968 → 6021
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:3082 → 3140
      C8; C8 domain
      cd19941
      Location:2360 → 2413
      TIL; trypsin inhibitor-like cysteine rich domain

    5. XM_063271283.1 → XP_063127353.1  zonadhesin isoform X4

    6. XM_063271284.1 → XP_063127354.1  zonadhesin isoform X5

    7. XM_063271285.1 → XP_063127355.1  zonadhesin isoform X6

    8. XM_039090054.2 → XP_038945982.1  zonadhesin isoform X3

      Related
      ENSRNOP00000078864.2, ENSRNOT00000115261.2
      Conserved Domains (10) summary
      smart00832
      Location:2672 → 2743
      C8; This domain contains 8 conserved cysteine residues
      PRK10811
      Location:1132 → 1333
      rne; ribonuclease E; Reviewed
      pfam05109
      Location:487 → 849
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12714
      Location:4788 → 4842
      TILa; TILa domain
      cl17735
      Location:6023 → 6076
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:2476 → 2631
      VWD; von Willebrand factor type D domain
      pfam00629
      Location:397 → 559
      MAM; MAM domain, meprin/A5/mu
      pfam01826
      Location:5968 → 6021
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:3082 → 3140
      C8; C8 domain
      cd19941
      Location:2360 → 2413
      TIL; trypsin inhibitor-like cysteine rich domain

    RNA

    1. XR_010056383.1 RNA Sequence

    2. XR_010056382.1 RNA Sequence

    3. XR_005491878.2 RNA Sequence

    4. XR_005491880.2 RNA Sequence

    5. XR_005491877.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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