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    Acin1 apoptotic chromatin condensation inducer 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305884, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acin1provided by RGD
    Official Full Name
    apoptotic chromatin condensation inducer 1provided by RGD
    Primary source
    RGD:1311945
    See related
    EnsemblRapid:ENSRNOG00000013533 AllianceGenome:RGD:1311945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including apoptotic chromosome condensation; negative regulation of mRNA splicing, via spliceosome; and positive regulation of monocyte differentiation. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be part of ASAP complex and exon-exon junction complex. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 247.0), Adrenal (RPKM 218.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Acin1 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32072121..32117004, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28102112..28147001, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33288369..33333256, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene cadherin 24 Neighboring gene similar to human chromosome 14 open reading frame 119 Neighboring gene ciliated left-right organizer metallopeptidase Neighboring gene CCAAT/enhancer binding protein epsilon

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding  
    Component Evidence Code Pubs
    part_of ASAP complex  
    part_of ASAP complex  
    located_in cytosol  
    located_in cytosol  
    part_of exon-exon junction complex  
    located_in nuclear speck  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    apoptotic chromatin condensation inducer in the nucleus
    Names
    acinus

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170468.1NP_001163939.1  apoptotic chromatin condensation inducer in the nucleus

      Status: VALIDATED

      Source sequence(s)
      AA925536, AI575776, CA512047, CB744719, CF110347, EV770592, FM029308, FM031419, FM033220, JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6AU50, E9PST5
      Related
      ENSRNOP00000018982.4, ENSRNOT00000018982.8
      Conserved Domains (3) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:10111097
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:11651240
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32072121..32117004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274245.1XP_063130315.1  apoptotic chromatin condensation inducer in the nucleus isoform X16

      UniProtKB/TrEMBL
      A0A8I6AU50
    2. XM_063274243.1XP_063130313.1  apoptotic chromatin condensation inducer in the nucleus isoform X14

      UniProtKB/TrEMBL
      A0A8I6AU50
    3. XM_063274240.1XP_063130310.1  apoptotic chromatin condensation inducer in the nucleus isoform X11

      UniProtKB/TrEMBL
      A0A8I6AU50
      Related
      ENSRNOP00000076634.2, ENSRNOT00000109889.2
    4. XM_063274241.1XP_063130311.1  apoptotic chromatin condensation inducer in the nucleus isoform X12

      UniProtKB/TrEMBL
      A0A8I6AU50
    5. XM_063274239.1XP_063130309.1  apoptotic chromatin condensation inducer in the nucleus isoform X6

      UniProtKB/TrEMBL
      A0A8I6AU50
    6. XM_006251960.5XP_006252022.1  apoptotic chromatin condensation inducer in the nucleus isoform X10

      UniProtKB/TrEMBL
      A0A8I5Y5F2, A0A8I6AU50
      Conserved Domains (3) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:9711057
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:11251200
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    7. XM_063274237.1XP_063130307.1  apoptotic chromatin condensation inducer in the nucleus isoform X4

      UniProtKB/TrEMBL
      A0A8I6AU50
    8. XM_063274242.1XP_063130312.1  apoptotic chromatin condensation inducer in the nucleus isoform X13

      UniProtKB/TrEMBL
      A0A8I6AU50
      Related
      ENSRNOP00000096887.2, ENSRNOT00000112466.2
    9. XM_006251959.5XP_006252021.1  apoptotic chromatin condensation inducer in the nucleus isoform X9

      UniProtKB/TrEMBL
      A0A8I6AU50
      Conserved Domains (3) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:9981084
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:11521227
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    10. XM_017599684.3XP_017455173.1  apoptotic chromatin condensation inducer in the nucleus isoform X7

      UniProtKB/TrEMBL
      A0A8I6AU50
    11. XM_063274235.1XP_063130305.1  apoptotic chromatin condensation inducer in the nucleus isoform X2

      UniProtKB/TrEMBL
      A0A8I6AU50
    12. XM_063274238.1XP_063130308.1  apoptotic chromatin condensation inducer in the nucleus isoform X5

      UniProtKB/TrEMBL
      A0A8I6AU50
    13. XM_006251958.5XP_006252020.1  apoptotic chromatin condensation inducer in the nucleus isoform X8

      UniProtKB/TrEMBL
      A0A8I6AU50
      Conserved Domains (3) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:9991085
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:11531228
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    14. XM_063274236.1XP_063130306.1  apoptotic chromatin condensation inducer in the nucleus isoform X3

      UniProtKB/TrEMBL
      A0A8I6AU50
    15. XM_063274234.1XP_063130304.1  apoptotic chromatin condensation inducer in the nucleus isoform X1

      UniProtKB/TrEMBL
      A0A8I6AU50
    16. XM_063274244.1XP_063130314.1  apoptotic chromatin condensation inducer in the nucleus isoform X15

      UniProtKB/TrEMBL
      A0A8I6AU50
    17. XM_063274247.1XP_063130317.1  apoptotic chromatin condensation inducer in the nucleus isoform X20

    18. XM_006251963.4XP_006252025.1  apoptotic chromatin condensation inducer in the nucleus isoform X19

      Related
      ENSRNOP00000090495.1, ENSRNOT00000111598.2
      Conserved Domains (2) summary
      cd12432
      Location:253339
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:407482
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    19. XM_063274246.1XP_063130316.1  apoptotic chromatin condensation inducer in the nucleus isoform X17

    20. XM_039093289.2XP_038949217.1  apoptotic chromatin condensation inducer in the nucleus isoform X18

      Conserved Domains (2) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      NF033804
      Location:680816
      Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin

    RNA

    1. XR_010057814.1 RNA Sequence

    2. XR_005493719.2 RNA Sequence

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