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    Arrdc3 arrestin domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309945, updated on 9-Dec-2024

    Summary

    Symbol
    Arrdc3provided by RGD
    Full Name
    arrestin domain containing 3provided by RGD
    Primary source
    RGD:1359478
    See related
    EnsemblRapid:ENSRNOG00000045649 AllianceGenome:RGD:1359478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00048
    Summary
    Predicted to enable beta-3 adrenergic receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis; positive regulation of hippo signaling; and protein transport. Predicted to act upstream of or within several processes, including fat pad development; negative regulation of locomotion involved in locomotory behavior; and positive regulation of ubiquitin-protein transferase activity. Predicted to be located in early endosome and lysosome. Predicted to be active in endosome and plasma membrane. Orthologous to human ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 774.4), Adrenal (RPKM 559.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Arrdc3 in Genome Data Viewer
    Location:
    2q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (12873202..12885716)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (11137464..11149978)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (8732907..8745445)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8, pseudogene 1 Neighboring gene thymine-DNA glycosylase, pseudogene 1 Neighboring gene uncharacterized LOC120100652 Neighboring gene UBX domain protein 1, pseudogene Neighboring gene uncharacterized LOC120100653

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in fat pad development  
    acts_upstream_of_or_within fat pad development  
    involved_in heat generation  
    acts_upstream_of heat generation  
    involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  
    acts_upstream_of_or_within negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  
    involved_in negative regulation of cold-induced thermogenesis  
    involved_in negative regulation of cold-induced thermogenesis  
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in negative regulation of heat generation  
    acts_upstream_of_or_within negative regulation of heat generation  
    involved_in negative regulation of locomotion involved in locomotory behavior  
    acts_upstream_of_or_within negative regulation of locomotion involved in locomotory behavior  
    involved_in positive regulation of hippo signaling  
    involved_in positive regulation of hippo signaling  
    acts_upstream_of_or_within positive regulation of ubiquitin-protein transferase activity  
    involved_in protein transport  
    involved_in skin development  
    acts_upstream_of_or_within skin development  
    acts_upstream_of_or_within temperature homeostasis  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in early endosome  
    is_active_in endosome  
    located_in endosome  
    located_in lysosome  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    arrestin domain-containing protein 3
    Names
    liver regeneration-related protein LRRG00048

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007797.2NP_001007798.1  arrestin domain-containing protein 3

      See identical proteins and their annotated locations for NP_001007798.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q6TXF1
      UniProtKB/TrEMBL
      A0A8L2QZ95, A6I4I1
      Related
      ENSRNOP00000078331.1, ENSRNOT00000106948.2
      Conserved Domains (2) summary
      smart01017
      Location:187314
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:22165
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RNA

    1. NR_178214.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      12873202..12885716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590815.3XP_017446304.1  arrestin domain-containing protein 3 isoform X1

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