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    Mars1 methionyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299851, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mars1provided by RGD
    Official Full Name
    methionyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:1305321
    See related
    EnsemblRapid:ENSRNOG00000025459 AllianceGenome:RGD:1305321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mars
    Summary
    Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to epidermal growth factor stimulus; and cellular response to platelet-derived growth factor stimulus. Part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 330.6), Adrenal (RPKM 302.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mars1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65006456..65023880, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63121142..63138550, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70585011..70602425, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene DDIT3 upstream open reading frame protein Neighboring gene DNA-damage inducible transcript 3 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 23 Neighboring gene Rho GTPase activating protein 9 Neighboring gene GLI family zinc finger 1 Neighboring gene inhibin subunit beta E

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables methionine-tRNA ligase activity  
    enables methionine-tRNA ligase activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex  
    part_of aminoacyl-tRNA synthetase multienzyme complex PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in nucleolus  

    General protein information

    Preferred Names
    methionine--tRNA ligase, cytoplasmic
    Names
    methionine-tRNA synthetase
    NP_001121131.1
    XP_006241513.1
    XP_038934683.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127659.1NP_001121131.1  methionine--tRNA ligase, cytoplasmic

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6A8E9, D3Z941
      Related
      ENSRNOP00000089312.1, ENSRNOT00000107571.2
      Conserved Domains (3) summary
      cd10307
      Location:77179
      GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
      PLN02610
      Location:258878
      PLN02610; probable methionyl-tRNA synthetase
      pfam18485
      Location:174
      GST_N_5; Glutathione S-transferase, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      65006456..65023880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241451.5XP_006241513.1  methionine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006241513.1

      UniProtKB/TrEMBL
      A0A8I5ZKR4, A0A8I6A8E9, A6HQU9
      Related
      ENSRNOP00000078365.1, ENSRNOT00000106342.2
      Conserved Domains (7) summary
      cd07957
      Location:644773
      Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
      cd00814
      Location:267635
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      cd10307
      Location:77179
      GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
      COG0625
      Location:47189
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      PRK12268
      Location:266821
      PRK12268; methionyl-tRNA synthetase; Reviewed
      cd00939
      Location:855899
      MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...
      cl00388
      Location:168
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    2. XM_039078755.2XP_038934683.1  methionine--tRNA ligase, cytoplasmic isoform X2

      Conserved Domains (2) summary
      PLN02610
      Location:1515
      PLN02610; probable methionyl-tRNA synthetase
      cd00939
      Location:531575
      MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...
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