Ptgdr prostaglandin D2 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ptgdrprovided by RGD
Full Name: prostaglandin D2 receptorprovided by RGD
Primary source: RGD:619707
See related: EnsemblRapid:ENSRNOG00000031535 AllianceGenome:RGD:619707
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptgdr2; Ptgdrl
Summary: Enables prostaglandin D receptor activity. Involved in negative regulation of cytosolic calcium ion concentration; positive regulation of penile erection; and vasodilation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR (prostaglandin D2 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (19790499..19797873)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (17360304..17367679)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (19195606..19196508)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
Title: Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
PGD2 receptor does not seem to be involved in the anti-enteropooling effect of PGD(2), since the selective agonists 13,14-dihydro-15-keto-PGD(2) and 15(R)-15-methyl-PGD(2) were without effect
Title: CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine.
amino acid sequence alignment of human, mouse and rat DP receptors (also called prostaglandin D2 receptor)
Title: The role of mast cells in asthma.

Submit: New GeneRIF Correction

General gene information

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Markers

D15Mit3 (e-PCR), detects polymorphism
- UniSTS:226670

BF391109 (e-PCR)
- UniSTS:249754

Ptgdr (e-PCR), detects polymorphism
- UniSTS:144289

PMC58788P1 (e-PCR)
- UniSTS:273373

D15Got105 (e-PCR)
- UniSTS:112866

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables prostaglandin D receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin D receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin D receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin D receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin J receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenosine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to prostaglandin D stimulus	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male sex determination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of penile erection	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sleep	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin D2 receptor-like

Names: prostaglandin D receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.