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    Ckb creatine kinase B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24264, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ckbprovided by RGD
    Official Full Name
    creatine kinase Bprovided by RGD
    Primary source
    RGD:2357
    See related
    EnsemblRapid:ENSRNOG00000010872 AllianceGenome:RGD:2357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ckbb; Ckbr; CPK-B
    Summary
    Predicted to enable creatine kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to estrogen stimulus; cellular response to wortmannin; and intracellular chloride ion homeostasis. Located in dendrite and neuronal cell body. Orthologous to human CKB (creatine kinase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 2087.7), Heart (RPKM 633.6) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Ckb in Genome Data Viewer
    Location:
    6q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136550583..136553464, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130729420..130732301, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136142956..136145838, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene eukaryotic translation initiation factor 5 Neighboring gene carnitine palmitoyltransferase 1A like 1 Neighboring gene microtubule affinity regulating kinase 3 Neighboring gene tRNA methyltransferase 61A Neighboring gene transfer RNA leucine (anticodon AAG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables creatine kinase activity  
    enables creatine kinase activity  
    enables creatine kinase activity  
    enables creatine kinase activity  
    enables protein binding PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    is_active_in extracellular space  
    located_in mitochondrion  
    is_active_in mitochondrion  
    is_active_in mitochondrion  
    located_in neuronal cell body PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    creatine kinase B-type
    Names
    B-CK
    brain creatine kinase
    creatine kinase B chain
    creatine kinase, brain
    creatine phosphokinase M-type
    NP_036661.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012529.3NP_036661.3  creatine kinase B-type

      See identical proteins and their annotated locations for NP_036661.3

      Status: VALIDATED

      Source sequence(s)
      BC127477, FM060701
      UniProtKB/Swiss-Prot
      A0JPK7, P07335, Q499P7, Q5PPJ5, Q6IRE0, Q6P139
      UniProtKB/TrEMBL
      A0A8L2Q875, A6KBS5
      Related
      ENSRNOP00000015122.4, ENSRNOT00000015122.7
      Conserved Domains (1) summary
      cd00716
      Location:16373
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      136550583..136553464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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