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    Adam3a ADAM metallopeptidase domain 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam3aprovided by RGD
    Official Full Name
    ADAM metallopeptidase domain 3Aprovided by RGD
    Primary source
    RGD:621469
    See related
    EnsemblRapid:ENSRNOG00000017554 AllianceGenome:RGD:621469
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adam3; tMDCI
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in male gonad development. Predicted to be located in cell surface; membrane raft; and sperm head. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in brain glioma and conjunctival squamous cell carcinoma. Orthologous to human ADAM3A (ADAM metallopeptidase domain 3A (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1114.3) See more
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    Genomic context

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    See Adam3a in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (74002566..74052579)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (67299949..67349970)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (72086878..72136685)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ADAM metallopeptidase domain 32 Neighboring gene ADAM metallopeptidase domain 5 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ADAM metallopeptidase domain 18 Neighboring gene uncharacterized LOC108348416 Neighboring gene indoleamine 2,3-dioxygenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of multiple DNA copy number alterations including frequent 8p11.22 amplification in conjunctival squamous cell carcinoma. Asnaghi L, et al. Invest Ophthalmol Vis Sci, 2014 Dec 9. PMID 25491297, Free PMC Article
    2. Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas. Barrow J, et al. Neuro Oncol, 2011 Feb. PMID 21138945, Free PMC Article
    3. Disruption of ADAM3 impairs the migration of sperm into oviduct in mouse. Yamaguchi R, et al. Biol Reprod, 2009 Jul. PMID 19339711
    4. Synthesis, processing, and subcellular localization of mouse ADAM3 during spermatogenesis and epididymal sperm transport. Kim E, et al. J Reprod Dev, 2004 Oct. PMID 15514464
    5. Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa. Yamaguchi R, et al. Mol Biol Cell, 2012 Jul. PMID 22621904, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADAM metallopeptidase domain 3A
    Names
    ADAM metallopeptidase domain 3
    ADAM metallopeptidase domain 3A (cyritestin 1)
    ADAM metallopeptidase domain 3A (pseudogene)
    a disintegrin and metallopeptidase domain 3 (cyritestin)
    a disintegrin and metalloprotease domain 3 (cyritestin)
    cyritestin
    tMDC I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020302.2 → NP_064698.1  ADAM metallopeptidase domain 3A precursor

      See identical proteins and their annotated locations for NP_064698.1

      Status: PROVISIONAL

      Source sequence(s)
      Y07903
      UniProtKB/TrEMBL
      D3ZSV4, P70534
      Related
      ENSRNOP00000099938.1, ENSRNOT00000121155.1
      Conserved Domains (6) summary
      smart00608
      Location:483 → 615
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:193 → 381
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:404 → 480
      Disintegrin; Disintegrin
      pfam01421
      Location:193 → 382
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40 → 141
      Pep_M12B_propep; Reprolysin family propeptide
      pfam01683
      Location:601 → 650
      EB; EB module

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      74002566..74052579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094792.2 → XP_038950720.1  ADAM metallopeptidase domain 3A isoform X1

      Conserved Domains (4) summary
      smart00050
      Location:210 → 285
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:289 → 421
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:1 → 187
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01683
      Location:407 → 456
      EB; EB module

    2. XM_039094793.2 → XP_038950721.1  ADAM metallopeptidase domain 3A isoform X2

      UniProtKB/TrEMBL
      A6IW31
      Conserved Domains (3) summary
      smart00050
      Location:58 → 133
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:137 → 269
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:1 → 35
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    Nucleotide Protein Strain
    Heading Accession and Version

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