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    Suds3 SDS3 homolog, SIN3A corepressor complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Suds3provided by RGD
    Official Full Name
    SDS3 homolog, SIN3A corepressor complex componentprovided by RGD
    Primary source
    RGD:1305986
    See related
    EnsemblRapid:ENSRNOG00000001139 AllianceGenome:RGD:1305986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305986
    Summary
    Predicted to enable histone deacetylase binding activity and identical protein binding activity. Predicted to contribute to histone deacetylase activity. Predicted to be involved in chromatin remodeling; negative regulation of transcription by RNA polymerase II; and substantia nigra development. Predicted to act upstream of or within blastocyst hatching and negative regulation of DNA-templated transcription. Predicted to be located in cytosol and nuclear body. Predicted to be part of Sin3-type complex. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 167.8), Lung (RPKM 148.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Suds3 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (45137964..45160413)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (39477181..39499633)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (45199012..45221507)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095992 Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene TAO kinase 3 Neighboring gene uncharacterized LOC120095860 Neighboring gene uncharacterized LOC102554374

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. Li Z, et al. J Biol Chem, 2004 Dec 24. PMID 15489224
    2. Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. Alland L, et al. Mol Cell Biol, 2002 Apr. PMID 11909966, Free PMC Article
    3. The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Icardi L, et al. Proc Natl Acad Sci U S A, 2012 Jul 24. PMID 22783022, Free PMC Article
    4. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. Ramakrishna S, et al. J Biol Chem, 2011 Mar 25. PMID 21239494, Free PMC Article
    5. Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Chen S, et al. Neurochem Res, 2012 Dec. PMID 22926577

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sin3 histone deacetylase corepressor complex component SDS3
    Names
    suppressor of defective silencing 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431820.1 → NP_001418749.1  sin3 histone deacetylase corepressor complex component SDS3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1P8

    2. NM_001431821.1 → NP_001418750.1  sin3 histone deacetylase corepressor complex component SDS3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1Q0

    3. NM_001431822.1 → NP_001418751.1  sin3 histone deacetylase corepressor complex component SDS3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1P8

    4. NM_001431823.1 → NP_001418752.1  sin3 histone deacetylase corepressor complex component SDS3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1Q0, M0RBT5

    5. NM_001431824.1 → NP_001418753.1  sin3 histone deacetylase corepressor complex component SDS3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      45137964..45160413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_341092.9 → XP_341093.4  sin3 histone deacetylase corepressor complex component SDS3 isoform X1

      Related
      ENSRNOP00000067032.4, ENSRNOT00000075646.5
      Conserved Domains (1) summary
      pfam08598
      Location:62 → 178
      Sds3; Sds3-like

    2. XM_039090182.2 → XP_038946110.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X2

      Conserved Domains (1) summary
      pfam08598
      Location:2 → 60
      Sds3; Sds3-like
    Nucleotide Protein Strain
    Heading Accession and Version

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