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    Ttc12 tetratricopeptide repeat domain 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc12provided by RGD
    Official Full Name
    tetratricopeptide repeat domain 12provided by RGD
    Primary source
    RGD:1303264
    See related
    EnsemblRapid:ENSRNOG00000008595 AllianceGenome:RGD:1303264
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be active in centrosome and cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alcohol dependence; drug dependence (multiple); nicotine dependence; and primary ciliary dyskinesia 45. Orthologous to human TTC12 (tetratricopeptide repeat domain 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 87.2), Kidney (RPKM 25.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttc12 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (58696381..58743857, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (49799916..49847940, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53770685..53818873, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dopamine receptor D2 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene uncharacterized LOC102555969 Neighboring gene neural cell adhesion molecule 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. Bidwell LC, et al. Psychopharmacology (Berl), 2015 Apr. PMID 25273375, Free PMC Article
    2. Hypermethylation of TTC12 gene in acute lymphoblastic leukemia. Wattanawaraporn R, et al. Leukemia, 2007 Nov. PMID 17657212
    3. A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response. Macare C, et al. Eur Neuropsychopharmacol, 2018 Oct. PMID 30104163, Free PMC Article
    4. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. Nelson EC, et al. JAMA Psychiatry, 2013 Mar. PMID 23303482, Free PMC Article
    5. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. Yang BZ, et al. Hum Mol Genet, 2007 Dec 1. PMID 17761687

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94947

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonemal dynein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004246.2 → NP_001004246.1  tetratricopeptide repeat protein 12

      See identical proteins and their annotated locations for NP_001004246.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079409
      UniProtKB/TrEMBL
      F7FHS8, Q68FR0
      Related
      ENSRNOP00000011454.6, ENSRNOT00000011454.7
      Conserved Domains (4) summary
      cd00020
      Location:612 → 704
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00006
      Location:105 → 133
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:142 → 172
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:105 → 170
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      58696381..58743857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243004.5 → XP_006243066.1  tetratricopeptide repeat protein 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GMH4, F7FHS8
      Related
      ENSRNOP00000097363.1, ENSRNOT00000102297.2
      Conserved Domains (4) summary
      cd00020
      Location:631 → 723
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00006
      Location:124 → 152
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:161 → 191
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:124 → 189
      TPR_11; TPR repeat

    2. XM_006243005.5 → XP_006243067.1  tetratricopeptide repeat protein 12 isoform X2

      See identical proteins and their annotated locations for XP_006243067.1

      UniProtKB/TrEMBL
      F7FHS8, Q68FR0
      Conserved Domains (4) summary
      cd00020
      Location:612 → 704
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00006
      Location:105 → 133
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:142 → 172
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:105 → 170
      TPR_11; TPR repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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