Agmo alkylglycerol monooxygenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agmoprovided by RGD
Official Full Name: alkylglycerol monooxygenaseprovided by RGD
Primary source: RGD:1312038
See related: EnsemblRapid:ENSRNOG00000023116 AllianceGenome:RGD:1312038
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem195; RGD1312038
Summary: Predicted to enable glyceryl-ether monooxygenase activity and iron ion binding activity. Predicted to be involved in ether lipid metabolic process; membrane lipid metabolic process; and triglyceride biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AGMO (alkylglycerol monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 750.5), Thymus (RPKM 42.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (59713495..60044851)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (53986236..54317838)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (56846859..57193918)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glyceryl-ether monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyceryl-ether monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables glyceryl-ether monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ether lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ether lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in membrane lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in membrane lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alkylglycerol monooxygenase

Names: transmembrane protein 195

NP_001129371.1

EC 1.14.16.5

XP_038968427.1

EC 1.14.16.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135899.1 → NP_001129371.1 alkylglycerol monooxygenase

See identical proteins and their annotated locations for NP_001129371.1

Status: PROVISIONAL

Source sequence(s)

BC127545

UniProtKB/Swiss-Prot

A0JPQ8

UniProtKB/TrEMBL

A0A8I6GIU1

Related

ENSRNOP00000029816.4, ENSRNOT00000032108.7

Conserved Domains (2) summary

COG3000
Location:43 → 276

ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]

pfam04116
Location:119 → 249

FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

59713495..60044851

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112499.2 → XP_038968427.1 alkylglycerol monooxygenase isoform X1

UniProtKB/TrEMBL

A0A8I6GIU1

Conserved Domains (1) summary

COG3000
Location:43 → 276

ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]