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    Il27ra interleukin 27 receptor subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288905, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Il27raprovided by RGD
    Official Full Name
    interleukin 27 receptor subunit alphaprovided by RGD
    Primary source
    RGD:1305029
    See related
    EnsemblRapid:ENSRNOG00000005747 AllianceGenome:RGD:1305029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable interleukin-27 receptor activity. Predicted to be involved in several processes, including negative regulation of T cell extravasation; negative regulation of T-helper 17 type immune response; and negative regulation of cytokine production. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of type II interferon production; and regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Orthologous to human IL27RA (interleukin 27 receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 49.9), Spleen (RPKM 33.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il27ra in Genome Data Viewer
    Location:
    19q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41014730..41026740)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24109963..24121977)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25151835..25163995, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene regulatory factor X1 Neighboring gene uncharacterized LOC102555451 Neighboring gene relaxin 3 Neighboring gene paralemmin 3 Neighboring gene microRNA 1199 Neighboring gene MISP family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation. Yoshizaki A, et al. Ann Rheum Dis, 2011 Jan. PMID 20705635
    2. Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling. Shimanoe Y, et al. Ann Allergy Asthma Immunol, 2009 Mar. PMID 19354069
    3. Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice. Miyazaki Y, et al. J Immunol, 2005 Aug 15. PMID 16081811
    4. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. Hölscher C, et al. J Immunol, 2005 Mar 15. PMID 15749890
    5. Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice. Koltsova EK, et al. Circ Res, 2012 Oct 26. PMID 22927332, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables interleukin-27 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of T cell extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T-helper 17 type immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of type 2 immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of T-helper 1 type immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of isotype switching to IgG isotypes ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-27 receptor subunit alpha
    Names
    interleukin 27 receptor, alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395124.1 → NP_001382053.1  interleukin-27 receptor subunit alpha precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IYB4, D4A6K5
      Related
      ENSRNOP00000007726.7, ENSRNOT00000007726.7
      Conserved Domains (1) summary
      cd00063
      Location:141 → 222
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      41014730..41026740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105943.1: Suppressed sequence

      Description
      NM_001105943.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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