Adam9 ADAM metallopeptidase domain 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adam9provided by RGD
Official Full Name: ADAM metallopeptidase domain 9provided by RGD
Primary source: RGD:621473
See related: EnsemblRapid:ENSRNOG00000017231 AllianceGenome:RGD:621473
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MDC9
Summary: Predicted to enable several functions, including SH3 domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and protein kinase C binding activity. Involved in response to antineoplastic agent and response to laminar fluid shear stress. Located in basolateral plasma membrane and cell surface. Biomarker of Alzheimer's disease and status epilepticus. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 255.8), Lung (RPKM 241.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.4

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (73725186..73804284)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (67022538..67101647)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (71810377..71887926)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAM9 was induced in dentate gyrus of hippocampus. The spatiotemporal expression of ADAM9 suggests that its regulation after the KA-induced status epilepticus could be related to neuroprotection.
Title: ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus.

Submit: New GeneRIF Correction

General gene information

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Markers

Adam9 (e-PCR), detects polymorphism
- UniSTS:471065

RH136732 (e-PCR)
- UniSTS:218821

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane protein intracellular domain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in monocyte activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in response to antineoplastic agent	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to laminar fluid shear stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese ion	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 9

Names: a disintegrin and metallopeptidase domain 9 (meltrin gamma); a disintegrin and metalloproteinase domain 9 (meltrin gamma); meltrin gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014772.2 → NP_001014772.2 disintegrin and metalloproteinase domain-containing protein 9 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

E9PTA4, Q58GH6

Related

ENSRNOP00000102349.1, ENSRNOT00000168882.1

Conserved Domains (6) summary

smart00050
Location:423 → 498

DISIN; Homologues of snake disintegrins

smart00608
Location:500 → 636

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:212 → 406

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:44 → 163

Pep_M12B_propep; Reprolysin family propeptide

pfam07974
Location:650 → 673

EGF_2; EGF-like domain

pfam15240
Location:732 → 802

Pro-rich; Proline-rich

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

73725186..73804284

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275248.1 → XP_063131318.1 disintegrin and metalloproteinase domain-containing protein 9 isoform X1

UniProtKB/TrEMBL

Q58GH6
XM_039094403.2 → XP_038950331.1 disintegrin and metalloproteinase domain-containing protein 9 isoform X2

UniProtKB/TrEMBL

Q58GH6

Related

ENSRNOP00000089910.2, ENSRNOT00000120151.2

Conserved Domains (6) summary

smart00050
Location:423 → 498

DISIN; Homologues of snake disintegrins

smart00608
Location:500 → 636

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:212 → 406

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:44 → 163

Pep_M12B_propep; Reprolysin family propeptide

pfam06346
Location:747 → 793

Drf_FH1; Formin Homology Region 1

pfam07974
Location:650 → 673

EGF_2; EGF-like domain
XM_063275249.1 → XP_063131319.1 disintegrin and metalloproteinase domain-containing protein 9 isoform X3

UniProtKB/TrEMBL

A0A8I6AAS7