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    Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309451, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gbf1provided by RGD
    Official Full Name
    golgi brefeldin A resistant guanine nucleotide exchange factor 1provided by RGD
    Primary source
    RGD:1307160
    See related
    EnsemblRapid:ENSRNOG00000026048 AllianceGenome:RGD:1307160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307160
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and protein localization to organelle. Located in Golgi stack; endoplasmic reticulum lumen; and peroxisome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate A. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 169.8), Heart (RPKM 139.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gbf1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254959784..255088479)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245018535..245147052)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265904616..266033107)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain 3 Neighboring gene ATP synthase membrane subunit g, pseudogene 12 Neighboring gene uncharacterized LOC134484079 Neighboring gene U6 spliceosomal RNA Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 7 Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene uncharacterized LOC134484075

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle  
    involved_in Golgi disassembly  
    involved_in Golgi organization  
    involved_in Golgi to endosome transport  
    involved_in biological_process  
    involved_in cell activation involved in immune response  
    involved_in cellular response to virus  
    involved_in endoplasmic reticulum-Golgi intermediate compartment organization  
    involved_in establishment of monopolar cell polarity  
    involved_in neutrophil chemotaxis  
    involved_in protein localization to Golgi apparatus  
    involved_in protein localization to endoplasmic reticulum exit site  
    involved_in protein localization to endoplasmic reticulum tubular network  
    involved_in reactive oxygen species biosynthetic process  
    involved_in regulation of ARF protein signal transduction  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of protein localization to cell surface  
    involved_in retrograde transport, endosome to Golgi  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in Golgi stack PubMed 
    located_in cell leading edge  
    located_in cis-Golgi network  
    located_in cytosol  
    located_in endoplasmic reticulum lumen PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment  
    located_in peroxisome PubMed 
    located_in trans-Golgi network  

    General protein information

    Preferred Names
    Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
    Names
    golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1
    golgi-specific brefeldin A-resistance factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191634.1NP_001178563.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (3) summary
      COG5307
      Location:4831162
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:699884
      Sec7; Sec7 domain
      pfam12783
      Location:400545
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      254959784..255088479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231500.5XP_006231562.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X8

      UniProtKB/TrEMBL
      A6JHL5
      Related
      ENSRNOP00000038037.7, ENSRNOT00000036156.7
      Conserved Domains (3) summary
      COG5307
      Location:4841163
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:700885
      Sec7; Sec7 domain
      pfam12783
      Location:401546
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    2. XM_006231501.5XP_006231563.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X9

      UniProtKB/TrEMBL
      A6JHL5, F1M8X9
      Conserved Domains (3) summary
      COG5307
      Location:4841163
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:700885
      Sec7; Sec7 domain
      pfam12783
      Location:401546
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    3. XM_006231502.5XP_006231564.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X10

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (3) summary
      COG5307
      Location:4831162
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:699884
      Sec7; Sec7 domain
      pfam12783
      Location:400545
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    4. XM_039080486.2XP_038936414.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (4) summary
      PHA03247
      Location:17561886
      PHA03247; large tegument protein UL36; Provisional
      COG5307
      Location:5101029
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:726911
      Sec7; Sec7 domain
      pfam12783
      Location:427572
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    5. XM_006231496.5XP_006231558.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (2) summary
      pfam01369
      Location:733918
      Sec7; Sec7 domain
      pfam12783
      Location:434579
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    6. XM_006231497.5XP_006231559.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (2) summary
      pfam01369
      Location:732917
      Sec7; Sec7 domain
      pfam12783
      Location:433578
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    7. XM_039080492.2XP_038936420.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X6

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (4) summary
      PHA03247
      Location:17551885
      PHA03247; large tegument protein UL36; Provisional
      COG5307
      Location:5091028
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:725910
      Sec7; Sec7 domain
      pfam12783
      Location:426571
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    8. XM_063264977.1XP_063121047.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X11

      UniProtKB/TrEMBL
      A6JHL5
    9. XM_063264979.1XP_063121049.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X12

      UniProtKB/TrEMBL
      A6JHL5
      Related
      ENSRNOP00000102549.1, ENSRNOT00000149376.1
    10. XM_006231498.5XP_006231560.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (2) summary
      pfam01369
      Location:733918
      Sec7; Sec7 domain
      pfam12783
      Location:434579
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    11. XM_063264948.1XP_063121018.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

      UniProtKB/TrEMBL
      A6JHL5
    12. XM_063264959.1XP_063121029.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X7

      UniProtKB/TrEMBL
      A6JHL5
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