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    Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288259, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gartprovided by RGD
    Official Full Name
    phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseprovided by RGD
    Primary source
    RGD:1308717
    See related
    EnsemblRapid:ENSRNOG00000028292 AllianceGenome:RGD:1308717
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; and phosphoribosylglycinamide formyltransferase activity. Involved in brainstem development; cerebellum development; and cerebral cortex development. Predicted to be active in cytosol. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 234.7), Spleen (RPKM 213.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gart in Genome Data Viewer
    Location:
    11q11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44351841..44377086, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30864896..30891125, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31780477..31805728, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 50B Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene SON DNA and RNA binding protein Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene crystallin zeta like 1 Neighboring gene intersectin 1 Neighboring gene uncharacterized LOC134481057

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process  
    involved_in 'de novo' IMP biosynthetic process  
    involved_in 'de novo' IMP biosynthetic process  
    involved_in 'de novo' XMP biosynthetic process  
    involved_in GMP biosynthetic process  
    involved_in adenine biosynthetic process  
    involved_in brainstem development PubMed 
    involved_in cerebellum development PubMed 
    involved_in cerebral cortex development PubMed 
    involved_in purine nucleotide biosynthetic process  
    Component Evidence Code Pubs
    is_active_in cytosol  
    is_active_in cytosol  

    General protein information

    Preferred Names
    trifunctional purine biosynthetic protein adenosine-3
    NP_001011899.2
    XP_017453430.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011899.2NP_001011899.2  trifunctional purine biosynthetic protein adenosine-3

      See identical proteins and their annotated locations for NP_001011899.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473989
      UniProtKB/TrEMBL
      A6JLG8, G3V918
      Related
      ENSRNOP00000033253.4, ENSRNOT00000032162.6
      Conserved Domains (7) summary
      cd02196
      Location:469767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK00885
      Location:4427
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      PRK05385
      Location:435766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      pfam01071
      Location:105298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      44351841..44377086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597941.3XP_017453430.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      UniProtKB/TrEMBL
      A6JLG8, G3V918
      Conserved Domains (7) summary
      cd02196
      Location:469767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK00885
      Location:4427
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      PRK05385
      Location:435766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      pfam01071
      Location:105298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain
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