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    Cant1 calcium activated nucleotidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246272, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cant1provided by RGD
    Official Full Name
    calcium activated nucleotidase 1provided by RGD
    Primary source
    RGD:628743
    See related
    EnsemblRapid:ENSRNOG00000003239 AllianceGenome:RGD:628743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    srapy
    Summary
    Predicted to enable calcium ion binding activity; nucleoside diphosphate phosphatase activity; and protein homodimerization activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction and proteoglycan biosynthetic process. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Desbuquois dysplasia and multiple epiphyseal dysplasia 7. Orthologous to human CANT1 (calcium activated nucleotidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 107.0), Adrenal (RPKM 73.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cant1 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (104135676..104148854, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103637079..103650240, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (107432500..107445634, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene CEP295 N-terminal like Neighboring gene galectin 3 binding protein Neighboring gene uncharacterized LOC102548791 Neighboring gene C1q and TNF related 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP phosphatase activity  
    enables GDP phosphatase activity  
    enables GDP phosphatase activity  
    enables UDP phosphatase activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables nucleoside diphosphate phosphatase activity  
    enables protein homodimerization activity  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi cisterna membrane  
    located_in endoplasmic reticulum membrane PubMed 
    located_in membrane  

    General protein information

    Preferred Names
    soluble calcium-activated nucleotidase 1
    Names
    SCAN-1
    apyrase homolog
    ectonucleoside triphosphate diphosphohydrolase 8
    NP_653355.1
    XP_006247851.1
    XP_006247852.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144754.2NP_653355.1  soluble calcium-activated nucleotidase 1

      See identical proteins and their annotated locations for NP_653355.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097279
      UniProtKB/Swiss-Prot
      Q4V8N9, Q8K4Y7
      UniProtKB/TrEMBL
      A0A8I6AAU4, A6HL53
      Related
      ENSRNOP00000059931.2, ENSRNOT00000066303.4
      Conserved Domains (1) summary
      pfam06079
      Location:116403
      Apyrase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      104135676..104148854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247790.3XP_006247852.1  soluble calcium-activated nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006247852.1

      UniProtKB/Swiss-Prot
      Q4V8N9, Q8K4Y7
      UniProtKB/TrEMBL
      A0A8I6AAU4, A6HL53
      Conserved Domains (1) summary
      pfam06079
      Location:116403
      Apyrase
    2. XM_006247789.5XP_006247851.1  soluble calcium-activated nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006247851.1

      UniProtKB/Swiss-Prot
      Q4V8N9, Q8K4Y7
      UniProtKB/TrEMBL
      A0A8I6AAU4, A6HL53
      Conserved Domains (1) summary
      pfam06079
      Location:116403
      Apyrase
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