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    Plin1 perilipin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25629, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plin1provided by RGD
    Official Full Name
    perilipin 1provided by RGD
    Primary source
    RGD:3351
    See related
    EnsemblRapid:ENSRNOG00000015086 AllianceGenome:RGD:3351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plin; PERIA
    Summary
    Predicted to be involved in negative regulation of lipid catabolic process. Predicted to act upstream of or within cellular response to cold and lipid catabolic process. Located in lipid droplet. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 4 and obesity. Orthologous to human PLIN1 (perilipin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 331.7), Thymus (RPKM 302.0) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Plin1 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143073612..143086199, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (133664294..133676854, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (141458907..141470927, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 7 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene uncharacterized LOC120099868 Neighboring gene peroxisomal biogenesis factor 11 alpha Neighboring gene WD repeat domain 93 Neighboring gene small nuclear ribonucleoprotein polypeptide E like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cell periphery  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in lipid droplet PubMed 
    located_in lipid droplet  
    located_in lipid droplet  
    located_in lipid droplet  

    General protein information

    Preferred Names
    perilipin-1
    Names
    PERI
    lipid droplet-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308145.1NP_001295074.1  perilipin-1

      See identical proteins and their annotated locations for NP_001295074.1

      Status: VALIDATED

      Source sequence(s)
      BU671441, FM042626, FM044716, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P43884
      UniProtKB/TrEMBL
      A6JC64, F1LSF5
      Related
      ENSRNOP00000061809.5, ENSRNOT00000065759.5
      Conserved Domains (1) summary
      pfam03036
      Location:14392
      Perilipin; Perilipin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143073612..143086199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759499.4XP_008757721.1  perilipin-1 isoform X1

      See identical proteins and their annotated locations for XP_008757721.1

      UniProtKB/Swiss-Prot
      P43884
      UniProtKB/TrEMBL
      A6JC64, F1LSF5
      Conserved Domains (1) summary
      pfam03036
      Location:14392
      Perilipin; Perilipin family

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