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    Ifngr2 interferon gamma receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360697, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ifngr2provided by RGD
    Official Full Name
    interferon gamma receptor 2provided by RGD
    Primary source
    RGD:1307532
    See related
    EnsemblRapid:ENSRNOG00000002032 AllianceGenome:RGD:1307532
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable type II interferon receptor activity. Involved in microglial cell activation and positive regulation of NMDA glutamate receptor activity. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 28. Orthologous to human IFNGR2 (interferon gamma receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 110.9), Spleen (RPKM 87.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ifngr2 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44265703..44283975)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30779733..30798005)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31694339..31712611)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene interferon alpha and beta receptor subunit 1 Neighboring gene small ribosomal subunit protein eS7-like Neighboring gene uncharacterized LOC134481058 Neighboring gene transmembrane protein 50B Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene SON DNA and RNA binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity  
    enables type II interferon receptor activity  
    Component Evidence Code Pubs
    is_active_in plasma membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    interferon gamma receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108313.1 → NP_001101783.1  interferon gamma receptor 2 precursor

      See identical proteins and their annotated locations for NP_001101783.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473989
      UniProtKB/TrEMBL
      A6JLG1, D4A109
      Related
      ENSRNOP00000002779.5, ENSRNOT00000002779.7
      Conserved Domains (1) summary
      cl21522
      Location:27 → 121
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      44265703..44283975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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