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    Lrrc8a leucine rich repeat containing 8 VRAC subunit A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311846, updated on 4-Jan-2025

    Summary

    Official Symbol
    Lrrc8aprovided by RGD
    Official Full Name
    leucine rich repeat containing 8 VRAC subunit Aprovided by RGD
    Primary source
    RGD:1311690
    See related
    EnsemblRapid:ENSRNOG00000025296 AllianceGenome:RGD:1311690
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrrc8
    Summary
    Enables volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; response to osmotic stress; and taurine transmembrane transport. Predicted to be located in cell surface and lysosomal membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Adrenal (RPKM 164.1), Heart (RPKM 148.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Lrrc8a in Genome Data Viewer
    Location:
    3p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33902299..33934989)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13509577..13537174)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8801544..8829506)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene kynurenine aminotransferase 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120101891 Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene nucleoporin 188 Neighboring gene dolichol kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in aspartate transmembrane transport  
    involved_in aspartate transmembrane transport PubMed 
    involved_in biological_process  
    involved_in cell volume homeostasis  
    involved_in cell volume homeostasis  
    involved_in chloride transmembrane transport  
    involved_in chloride transmembrane transport  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular signal transduction  
    involved_in monoatomic anion transmembrane transport  
    involved_in monoatomic anion transmembrane transport  
    involved_in monoatomic anion transmembrane transport  
    involved_in monoatomic anion transport  
    involved_in monoatomic anion transport  
    involved_in monoatomic ion transmembrane transport  
    involved_in positive regulation of insulin secretion  
    involved_in positive regulation of insulin secretion  
    involved_in positive regulation of myoblast differentiation  
    involved_in positive regulation of myoblast differentiation  
    involved_in pre-B cell differentiation  
    involved_in pre-B cell differentiation  
    involved_in protein hexamerization  
    involved_in protein hexamerization  
    involved_in response to osmotic stress PubMed 
    involved_in response to osmotic stress  
    involved_in response to osmotic stress  
    involved_in spermatogenesis  
    involved_in spermatogenesis  
    involved_in taurine transmembrane transport PubMed 
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    located_in cell surface  
    is_active_in cytoplasm  
    located_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in membrane  
    located_in membrane  
    part_of monoatomic ion channel complex  
    part_of monoatomic ion channel complex  
    part_of monoatomic ion channel complex  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    volume-regulated anion channel subunit LRRC8A
    Names
    leucine rich repeat containing 8 family, member A
    leucine rich repeat containing 8A
    leucine-rich repeat-containing 8
    leucine-rich repeat-containing protein 8A
    swelling protein 1 SWELL1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024782.1NP_001019953.1  volume-regulated anion channel subunit LRRC8A

      See identical proteins and their annotated locations for NP_001019953.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097371
      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
      Related
      ENSRNOP00000031726.4, ENSRNOT00000033934.7
      Conserved Domains (3) summary
      COG4886
      Location:510767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1340
      Pannexin_like; Pannexin-like TM region of LRRC8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33902299..33934989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105233.2XP_038961161.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
      Conserved Domains (3) summary
      COG4886
      Location:510767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1340
      Pannexin_like; Pannexin-like TM region of LRRC8
    2. XM_063283945.1XP_063140015.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
    3. XM_017591840.3XP_017447329.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
      Conserved Domains (3) summary
      COG4886
      Location:510767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1340
      Pannexin_like; Pannexin-like TM region of LRRC8
    4. XM_063283944.1XP_063140014.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
    5. XM_017591841.3XP_017447330.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
      Conserved Domains (3) summary
      COG4886
      Location:510767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1340
      Pannexin_like; Pannexin-like TM region of LRRC8
    6. XM_063283942.1XP_063140012.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
    7. XM_039105234.2XP_038961162.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
      Conserved Domains (3) summary
      COG4886
      Location:510767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1340
      Pannexin_like; Pannexin-like TM region of LRRC8
    8. XM_063283946.1XP_063140016.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
    9. XM_017591842.3XP_017447331.1  volume-regulated anion channel subunit LRRC8A isoform X1

      UniProtKB/Swiss-Prot
      Q4V8I7
      UniProtKB/TrEMBL
      A0A8L2R553, A6JTW3
      Conserved Domains (3) summary
      COG4886
      Location:510767
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1340
      Pannexin_like; Pannexin-like TM region of LRRC8
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