Nop10 NOP10 ribonucleoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nop10provided by RGD
Official Full Name: NOP10 ribonucleoproteinprovided by RGD
Primary source: RGD:1582780
See related: EnsemblRapid:ENSRNOG00000005184 AllianceGenome:RGD:1582780
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nola3
Summary: Predicted to enable box H/ACA snoRNA binding activity and telomerase RNA binding activity. Involved in snoRNA guided rRNA pseudouridine synthesis. Part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 307.9), Thymus (RPKM 286.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (119521255..119522340)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (99066857..99067942)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (103747654..103748739)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables box H/ACA snoRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables telomerase RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in rRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in snoRNA guided rRNA pseudouridine synthesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within telomerase RNA localization to Cajal body	ISO Inferred from Sequence Orthology more info	PubMed
involved_in telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of box H/ACA snoRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of box H/ACA snoRNP complex	IDA Inferred from Direct Assay more info	PubMed
part_of box H/ACA snoRNP complex	ISO Inferred from Sequence Orthology more info
part_of box H/ACA telomerase RNP complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: H/ACA ribonucleoprotein complex subunit 3

Names: NOP10 ribonucleoprotein homolog; nucleolar protein family A, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.