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    Serpini1 serpin family I member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116459, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpini1provided by RGD
    Official Full Name
    serpin family I member 1provided by RGD
    Primary source
    RGD:619896
    See related
    EnsemblRapid:ENSRNOG00000010248 AllianceGenome:RGD:619896
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PI-12; raPIT5a
    Summary
    Enables serine-type endopeptidase inhibitor activity. Involved in positive regulation of neuron projection development. Predicted to be located in neuronal cell body and secretory granule lumen. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINI1 (serpin family I member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 478.8), Adrenal (RPKM 37.1) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Serpini1 in Genome Data Viewer
    Location:
    2q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (162645209..162731737)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (160346403..160433135)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (174013058..174111693)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 49 Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene programmed cell death 10 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108350036 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasmic vesicle lumen  
    located_in cytoplasmic vesicle lumen  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in perikaryon  
    located_in secretory granule lumen  

    General protein information

    Preferred Names
    neuroserpin
    Names
    peptidase inhibitor 12
    protease inhibitor 17
    serine (or cysteine) peptidase inhibitor, clade I, member 1
    serine (or cysteine) proteinase inhibitor clade member 1
    serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
    serine protease inhibitor 17
    serpin I1
    serpin peptidase inhibitor, clade I (neuroserpin), member 1
    serpin peptidase inhibitor, clade I, member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053779.2NP_446231.1  neuroserpin precursor

      See identical proteins and their annotated locations for NP_446231.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9JLD1, Q9JLD2
      UniProtKB/TrEMBL
      A6J5Q7
      Related
      ENSRNOP00000013905.5, ENSRNOT00000013904.8
      Conserved Domains (1) summary
      cd02048
      Location:23410
      neuroserpin; Neuroserpin is a inhibitory member of the SERine Proteinase INhibitor (serpin) family that reacts preferentially with tissue-type plasminogen activator (tPA). It is located in neurons in regions of the brain where tPA is also found, suggesting that ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      162645209..162731737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281153.1XP_063137223.1  neuroserpin isoform X1

      UniProtKB/Swiss-Prot
      Q9JLD1, Q9JLD2
      UniProtKB/TrEMBL
      A6J5Q7
    2. XM_008761076.4XP_008759298.1  neuroserpin isoform X1

      See identical proteins and their annotated locations for XP_008759298.1

      UniProtKB/Swiss-Prot
      Q9JLD1, Q9JLD2
      UniProtKB/TrEMBL
      A6J5Q7
      Related
      ENSRNOP00000108926.1, ENSRNOT00000151818.1
      Conserved Domains (1) summary
      cd02048
      Location:23410
      neuroserpin; Neuroserpin is a inhibitory member of the SERine Proteinase INhibitor (serpin) family that reacts preferentially with tissue-type plasminogen activator (tPA). It is located in neurons in regions of the brain where tPA is also found, suggesting that ...
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