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    Rock2 Rho-associated coiled-coil containing protein kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25537, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rock2provided by RGD
    Official Full Name
    Rho-associated coiled-coil containing protein kinase 2provided by RGD
    Primary source
    RGD:3590
    See related
    EnsemblRapid:ENSRNOG00000004496 AllianceGenome:RGD:3590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ROK; ROCK-II
    Summary
    Predicted to enable Rho-dependent protein serine/threonine kinase activity; endopeptidase activator activity; and protease binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of connective tissue replacement; and positive regulation of cytokine production. Acts upstream of or within Rho protein signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and spindle pole centrosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 488.3), Lung (RPKM 320.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rock2 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (45407823..45502773)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (39679116..39774033)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42180864..42289910)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene neurotensin receptor 2 Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene E2F transcription factor 6 Neighboring gene uncharacterized LOC134479346 Neighboring gene solute carrier family 66 member 3 Neighboring gene ciliary microtubule inner protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 35
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables endopeptidase activator activity  
    enables endopeptidase activator activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables kinase activity PubMed 
    enables metal ion binding  
    enables protease binding  
    enables protease binding  
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    enables small GTPase binding  
    Items 1 - 25 of 35
    Items 1 - 25 of 87
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction  
    acts_upstream_of_or_within Rho protein signal transduction PubMed 
    involved_in Rho protein signal transduction  
    involved_in actin cytoskeleton organization  
    acts_upstream_of_or_within actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in actomyosin structure organization  
    involved_in aortic valve morphogenesis  
    involved_in blood vessel diameter maintenance  
    involved_in cellular response to acetylcholine  
    involved_in cellular response to testosterone stimulus  
    involved_in cellular response to testosterone stimulus  
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in centrosome duplication  
    acts_upstream_of centrosome duplication  
    involved_in centrosome duplication  
    involved_in chromatin remodeling  
    involved_in chromosome condensation PubMed 
    involved_in cortical actin cytoskeleton organization  
    acts_upstream_of_or_within dendrite morphogenesis  
    involved_in embryonic morphogenesis  
    involved_in epithelial to mesenchymal transition  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in mRNA destabilization  
    involved_in mitotic cytokinesis  
    involved_in modulation by host of viral process  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of bicellular tight junction assembly  
    involved_in negative regulation of bicellular tight junction assembly  
    involved_in negative regulation of biomineral tissue development  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of nitric oxide biosynthetic process  
    involved_in negative regulation of nitric oxide biosynthetic process  
    involved_in negative regulation of protein localization to lysosome  
    involved_in negative regulation of protein localization to lysosome  
    acts_upstream_of_or_within neural tube closure  
    involved_in peptidyl-threonine phosphorylation  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of amyloid precursor protein catabolic process  
    involved_in positive regulation of amyloid-beta formation  
    involved_in positive regulation of amyloid-beta formation  
    involved_in positive regulation of cardiac muscle hypertrophy PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of centrosome duplication  
    acts_upstream_of_or_within positive regulation of centrosome duplication  
    involved_in positive regulation of connective tissue growth factor production PubMed 
    involved_in positive regulation of connective tissue replacement PubMed 
    involved_in positive regulation of connective tissue replacement  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of fibroblast growth factor production PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of protein localization to early endosome  
    involved_in positive regulation of protein localization to early endosome  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in postsynaptic actin cytoskeleton organization  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of angiotensin-activated signaling pathway  
    involved_in regulation of cell junction assembly  
    involved_in regulation of cellular response to hypoxia  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of keratinocyte differentiation  
    involved_in regulation of keratinocyte differentiation  
    involved_in regulation of nervous system process  
    involved_in regulation of synapse maturation  
    involved_in response to angiotensin  
    involved_in response to ischemia  
    involved_in response to transforming growth factor beta PubMed 
    involved_in response to transforming growth factor beta  
    involved_in rhythmic process  
    involved_in smooth muscle contraction  
    Items 1 - 25 of 87
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse  
    is_active_in centrosome  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic ribonucleoprotein granule  
    is_active_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in endomembrane system  
    is_active_in glutamatergic synapse  
    is_active_in neuromuscular junction  
    located_in nucleus  
    located_in plasma membrane  
    is_active_in postsynaptic density  
    is_active_in presynaptic active zone  
    located_in spindle pole centrosome  

    General protein information

    Preferred Names
    rho-associated protein kinase 2
    Names
    ROKalpha
    Rho-associated coiled-coil forming kinase 2
    RhoA - binding serine/threosine kinase alpha (ROK - alpha)
    p150 ROK-alpha
    p164 ROCK-2
    rho-associated, coiled-coil-containing protein kinase 2
    rho-associated, coiled-coil-containing protein kinase II
    rhoA-binding kinase 2
    NP_037154.2
    XP_006239971.1
    XP_038967738.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013022.2NP_037154.2  rho-associated protein kinase 2

      Status: VALIDATED

      Source sequence(s)
      BF398321, CB691694, CK475383, JAXUCZ010000006, U38481
      UniProtKB/Swiss-Prot
      Q62868
      UniProtKB/TrEMBL
      A0A0G2K5N6
      Related
      ENSRNOP00000073496.1, ENSRNOT00000090816.3
      Conserved Domains (7) summary
      cd11638
      Location:505571
      HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
      smart00220
      Location:92354
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:4371101
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:12611307
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:11511257
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05621
      Location:39417
      STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
      pfam08912
      Location:9791046
      Rho_Binding; Rho Binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      45407823..45502773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239909.5XP_006239971.1  rho-associated protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      F1LQT3
      Related
      ENSRNOP00000088194.2, ENSRNOT00000119147.2
      Conserved Domains (7) summary
      cd11638
      Location:505571
      HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
      smart00220
      Location:92354
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:4371101
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:12611307
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:11511257
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05621
      Location:39417
      STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
      pfam08912
      Location:9791046
      Rho_Binding; Rho Binding
    2. XM_039111810.2XP_038967738.2  rho-associated protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A6HAT7
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