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    G3bp1 G3BP stress granule assembly factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171092, updated on 9-Dec-2024

    Summary

    Official Symbol
    G3bp1provided by RGD
    Official Full Name
    G3BP stress granule assembly factor 1provided by RGD
    Primary source
    RGD:621140
    See related
    EnsemblRapid:ENSRNOG00000013186 AllianceGenome:RGD:621140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G3bp; RGD1310666
    Summary
    Predicted to enable several functions, including helicase activity; molecular condensate scaffold activity; and ribosomal small subunit binding activity. Predicted to be involved in several processes, including positive regulation of stress granule assembly; positive regulation of type I interferon production; and stress granule assembly. Predicted to act upstream of or within negative regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human G3BP1 (G3BP stress granule assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 268.3), Heart (RPKM 252.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See G3bp1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (40087533..40120931)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (39586864..39620268)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (40812858..40846252)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene antioxidant 1 copper chaperone Neighboring gene small nucleolar RNA, H/ACA box 29 Neighboring gene glycine receptor, alpha 1 Neighboring gene protein UXT pseudogene Neighboring gene high mobility group box 1 like 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA helicase activity  
    enables DNA helicase activity  
    enables DNA/RNA helicase activity  
    enables DNA/RNA helicase activity  
    enables RNA helicase activity  
    enables RNA helicase activity  
    enables mRNA binding  
    enables mRNA binding  
    enables molecular condensate scaffold activity  
    enables ribosomal small subunit binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytoplasmic stress granule  
    is_active_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule  
    is_active_in cytosol  
    located_in cytosol  

    General protein information

    Preferred Names
    ras GTPase-activating protein-binding protein 1
    Names
    GTPase activating protein (SH3 domain) binding protein 1
    Ras-GTPase-activating protein SH3-domain binding protein 1
    NP_598249.1
    XP_038941049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133565.1NP_598249.1  ras GTPase-activating protein-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A7W1, D3ZYS7
      Related
      ENSRNOP00000018149.4, ENSRNOT00000018149.8
      Conserved Domains (3) summary
      PHA03247
      Location:216328
      PHA03247; large tegument protein UL36; Provisional
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12463
      Location:335414
      RRM_G3BP1; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      40087533..40120931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085121.2XP_038941049.1  ras GTPase-activating protein-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7W1, D3ZYS7
      Related
      ENSRNOP00000087131.1, ENSRNOT00000110533.2
      Conserved Domains (3) summary
      PHA03247
      Location:216328
      PHA03247; large tegument protein UL36; Provisional
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12463
      Location:335414
      RRM_G3BP1; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins
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