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    Myd88 MYD88, innate immune signal transduction adaptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301059, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myd88provided by RGD
    Official Full Name
    MYD88, innate immune signal transduction adaptorprovided by RGD
    Primary source
    RGD:735043
    See related
    EnsemblRapid:ENSRNOG00000013634 AllianceGenome:RGD:735043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables Toll binding activity and interleukin-1 receptor binding activity. Involved in several processes, including JNK cascade; cell surface receptor signaling pathway; and positive regulation of smooth muscle cell proliferation. Part of protein-containing complex. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); hepatocellular carcinoma; lung cancer (multiple); lymphoma (multiple); and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 125.3), Thymus (RPKM 106.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Myd88 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127952161..127956230, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119074439..119078508, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128022512..128027462, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene oxidative stress responsive kinase 1 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 7 Neighboring gene uncharacterized LOC120094290 Neighboring gene acetyl-CoA acyltransferase 1A Neighboring gene xylulokinase Neighboring gene activin A receptor type 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP-dependent histone chaperone activity  
    enables TIR domain binding  
    enables TIR domain binding  
    enables Toll binding PubMed 
    enables Toll-like receptor binding  
    enables Toll-like receptor binding  
    enables identical protein binding  
    enables interleukin-1 receptor binding PubMed 
    enables interleukin-1 receptor binding  
    enables molecular adaptor activity  
    enables protein binding PubMed 
    enables signaling adaptor activity  
    enables signaling receptor binding PubMed 
    Items 1 - 25 of 89
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization  
    involved_in JNK cascade PubMed 
    acts_upstream_of JNK cascade  
    involved_in MyD88-dependent toll-like receptor signaling pathway  
    acts_upstream_of_or_within MyD88-dependent toll-like receptor signaling pathway  
    involved_in Toll signaling pathway  
    involved_in Toll signaling pathway PubMed 
    involved_in apoptotic process  
    acts_upstream_of_or_within cell surface receptor signaling pathway  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus  
    involved_in chromatin organization  
    involved_in chromatin remodeling  
    involved_in cytokine-mediated signaling pathway PubMed 
    involved_in defense response to Gram-positive bacterium  
    acts_upstream_of_or_within defense response to Gram-positive bacterium  
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to bacterium  
    involved_in defense response to protozoan  
    involved_in defense response to virus  
    involved_in defense response to virus  
    acts_upstream_of_or_within establishment of endothelial intestinal barrier  
    acts_upstream_of_or_within gene expression  
    involved_in gene expression  
    acts_upstream_of_or_within immunoglobulin mediated immune response  
    acts_upstream_of_or_within induced systemic resistance  
    involved_in inflammatory response  
    acts_upstream_of_or_within inflammatory response  
    involved_in innate immune response  
    involved_in innate immune response  
    involved_in interleukin-1-mediated signaling pathway  
    involved_in interleukin-33-mediated signaling pathway  
    acts_upstream_of_or_within leukocyte activation involved in inflammatory response  
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway  
    acts_upstream_of_or_within microglia differentiation  
    acts_upstream_of_or_within neurogenesis  
    acts_upstream_of_or_within neutrophil activation involved in immune response  
    acts_upstream_of_or_within neutrophil-mediated killing of bacterium  
    involved_in phagocytosis  
    acts_upstream_of_or_within positive regulation of JNK cascade  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of chemokine production  
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-17 production  
    involved_in positive regulation of interleukin-23 production  
    acts_upstream_of_or_within positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-8 production  
    acts_upstream_of_or_within positive regulation of lymphocyte proliferation  
    acts_upstream_of_or_within positive regulation of macrophage cytokine production  
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type I interferon production  
    acts_upstream_of_or_within regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of chemokine (C-X-C motif) ligand 1 production  
    acts_upstream_of_or_within regulation of chemokine (C-X-C motif) ligand 2 production  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of inflammatory response  
    acts_upstream_of_or_within regulation of interleukin-6 production  
    acts_upstream_of_or_within regulation of neutrophil migration  
    acts_upstream_of_or_within regulation of tumor necrosis factor production  
    involved_in response to amine PubMed 
    involved_in response to amino acid PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to interleukin-1  
    acts_upstream_of_or_within response to lipopolysaccharide  
    acts_upstream_of_or_within response to molecule of fungal origin  
    acts_upstream_of_or_within response to peptidoglycan  
    acts_upstream_of_or_within response to virus  
    involved_in skin development  
    involved_in toll-like receptor 4 signaling pathway  
    involved_in toll-like receptor 4 signaling pathway  
    involved_in toll-like receptor 5 signaling pathway  
    involved_in toll-like receptor 8 signaling pathway  
    involved_in toll-like receptor 8 signaling pathway  
    involved_in toll-like receptor TLR6:TLR2 signaling pathway  
    involved_in type I interferon-mediated signaling pathway  
    Items 1 - 25 of 89
    Component Evidence Code Pubs
    is_active_in cell surface  
    located_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in extrinsic component of cytoplasmic side of plasma membrane  
    is_active_in extrinsic component of plasma membrane  
    located_in nucleus  
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    myeloid differentiation primary response protein MyD88
    Names
    myeloid differentiation primary response 88
    myeloid differentiation primary response gene 88

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198130.2NP_937763.2  myeloid differentiation primary response protein MyD88

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4QRC0, Q6Y1S1
      UniProtKB/TrEMBL
      A0A8I6AAN0, A6I3W0
      Related
      ENSRNOP00000018341.3, ENSRNOT00000018341.7
      Conserved Domains (2) summary
      smart00255
      Location:161296
      TIR; Toll - interleukin 1 - resistance
      cd08312
      Location:29106
      Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      127952161..127956230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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