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    Castor1 cytosolic arginine sensor for mTORC1 subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360969, updated on 9-Dec-2024

    Summary

    Official Symbol
    Castor1provided by RGD
    Official Full Name
    cytosolic arginine sensor for mTORC1 subunit 1provided by RGD
    Primary source
    RGD:1304774
    See related
    EnsemblRapid:ENSRNOG00000006740 AllianceGenome:RGD:1304774
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gatsl3; RGD1304774
    Summary
    Predicted to enable several functions, including arginine binding activity; identical protein binding activity; and protein sequestering activity. Predicted to be involved in cellular response to L-arginine; cellular response to amino acid starvation; and regulation of TORC1 signaling. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol. Orthologous to human CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 86.2), Lung (RPKM 51.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Castor1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83309710..83314123)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79086136..79090549)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84447552..84457396)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 157 Neighboring gene splicing factor 3A subunit 1 Neighboring gene TBC1 domain family, member 10a Neighboring gene oncostatin M Neighboring gene LIF, interleukin 6 family cytokine

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC109140

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arginine binding  
    enables arginine binding  
    enables arginine binding  
    enables identical protein binding  
    enables molecular sensor activity  
    enables protein sequestering activity  
    enables protein sequestering activity  
    Process Evidence Code Pubs
    involved_in cellular response to L-arginine  
    involved_in cellular response to L-arginine  
    involved_in cellular response to L-arginine  
    involved_in cellular response to amino acid starvation  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of TORC1 signaling  
    involved_in positive regulation of TORC1 signaling  
    Component Evidence Code Pubs
    part_of GATOR2 complex  
    part_of GATOR2 complex  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  

    General protein information

    Preferred Names
    cytosolic arginine sensor for mTORC1 subunit 1
    Names
    GATS protein-like 3
    GATS-like protein 3
    Gats protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025128.1NP_001020299.1  cytosolic arginine sensor for mTORC1 subunit 1

      See identical proteins and their annotated locations for NP_001020299.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091274
      UniProtKB/Swiss-Prot
      Q5BJZ0
      UniProtKB/TrEMBL
      A6IKF4
      Related
      ENSRNOP00000009150.4, ENSRNOT00000009150.8
      Conserved Domains (2) summary
      pfam13840
      Location:257321
      ACT_7; ACT domain
      pfam18700
      Location:969
      Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      83309710..83314123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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