Gjc2 gap junction protein, gamma 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gjc2provided by RGD
Official Full Name: gap junction protein, gamma 2provided by RGD
Primary source: RGD:1562712
See related: EnsemblRapid:ENSRNOG00000038328 AllianceGenome:RGD:1562712
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cx47; Gja12
Summary: Predicted to enable gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of calcium ion transmembrane transport; and positive regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including paranode region of axon; perikaryon; and proximal neuron projection. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (gap junction protein gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 54.1), Lung (RPKM 12.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44462203..44470924, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (43962642..43971358, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45526740..45535520, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of Chi3l1 expression.
Title: Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of Chi3l1 expression.
Astrocytes regulate the expression of S1pR3 in oligodendrocyte progenitor cells via Cx47, which could be a valuable approach for promoting oligodendrocyte progenitor cells proliferation.
Title: Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation.
Astrocytes can cause Ca(2+) signaling activation, ERK1/2 phosphorylation, and Id4 expression stimulation in oligodendrocyte progenitor cells inducing proliferation of these cells, mainly through Cx47.
Title: Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of the ERK/Id4 pathway.
The study suggested that Cx47 play a key role in myelination.
Title: Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129753 (e-PCR)
- UniSTS:213046

RH143586 (e-PCR)
- UniSTS:232832

RH140806 (e-PCR)
- UniSTS:222872

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction channel activity	ISO Inferred from Sequence Orthology more info
enables gap junction channel activity involved in cell communication by electrical coupling	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell communication by electrical coupling	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte progenitor proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in paranode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in proximal neuron projection	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gap junction gamma-2 protein

Names: connexin-47; gap junction alpha-12 protein; gap junction membrane channel protein alpha 12; gap junction protein, alpha 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100784.1 → NP_001094254.1 gap junction gamma-2 protein

See identical proteins and their annotated locations for NP_001094254.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q80XF7

Related

ENSRNOP00000064383.1, ENSRNOT00000058362.5

Conserved Domains (3) summary

smart00037
Location:45 → 78

CNX; Connexin homologues

smart01089
Location:222 → 288

Connexin_CCC; Gap junction channel protein cysteine-rich domain

pfam00029
Location:5 → 289

Connexin; Connexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

44462203..44470924 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246515.5 → XP_006246577.1 gap junction gamma-2 protein isoform X3

See identical proteins and their annotated locations for XP_006246577.1

UniProtKB/Swiss-Prot

Q80XF7

Conserved Domains (3) summary

smart00037
Location:45 → 78

CNX; Connexin homologues

smart01089
Location:222 → 288

Connexin_CCC; Gap junction channel protein cysteine-rich domain

pfam00029
Location:5 → 289

Connexin; Connexin
XM_039086565.2 → XP_038942493.1 gap junction gamma-2 protein isoform X1

Related

ENSRNOP00000102028.1, ENSRNOT00000167661.1

Conserved Domains (1) summary

pfam00029
Location:96 → 381

Connexin
XM_063269613.1 → XP_063125683.1 gap junction gamma-2 protein isoform X2
XM_039086566.2 → XP_038942494.1 gap junction gamma-2 protein isoform X4

Conserved Domains (1) summary

pfam00029
Location:108 → 198

Connexin