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    Cox5b cytochrome c oxidase subunit 5B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94194, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cox5bprovided by RGD
    Official Full Name
    cytochrome c oxidase subunit 5Bprovided by RGD
    Primary source
    RGD:620608
    See related
    EnsemblRapid:ENSRNOG00000016660 AllianceGenome:RGD:620608
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytochrome-c oxidase activity. Involved in response to peptide hormone and response to thyroid hormone. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Biomarker of hypertension. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 6855.5), Muscle (RPKM 4494.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Cox5b in Genome Data Viewer
    Location:
    9q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46417735..46419664)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38921980..38923806)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43259706..43262039)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 178, member B Neighboring gene uncharacterized LOC120094668 Neighboring gene actin related protein 1B Neighboring gene similar to human chromosome 2 open reading frame 92 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in mitochondrial inner membrane  
    located_in mitochondrial membrane  
    located_in mitochondrion  
    part_of respiratory chain complex IV  

    General protein information

    Preferred Names
    cytochrome c oxidase subunit 5B, mitochondrial
    Names
    cytochrome c oxidase polypeptide Vb
    cytochrome c oxidase subunit VIA*
    cytochrome c oxidase subunit Vb
    NP_446038.1
    XP_063123859.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053586.2NP_446038.1  cytochrome c oxidase subunit 5B, mitochondrial precursor

      See identical proteins and their annotated locations for NP_446038.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P12075
      UniProtKB/TrEMBL
      A0A8L2QBW2, A6INE7
      Related
      ENSRNOP00000022487.3, ENSRNOT00000022487.7
      Conserved Domains (1) summary
      cd00924
      Location:32124
      Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      46417735..46419664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267789.1XP_063123859.1  cytochrome c oxidase subunit 5B, mitochondrial isoform X1

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