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    Mak male germ cell-associated kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25677, updated on 9-Dec-2024

    Summary

    Official Symbol
    Makprovided by RGD
    Official Full Name
    male germ cell-associated kinaseprovided by RGD
    Primary source
    RGD:3036
    See related
    EnsemblRapid:ENSRNOG00000015101 AllianceGenome:RGD:3036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in several processes, including cilium organization; photoreceptor cell maintenance; and protein autophosphorylation. Predicted to act upstream of or within negative regulation of non-motile cilium assembly. Predicted to be located in several cellular components, including cytoskeleton; midbody; and photoreceptor cell cilium. Predicted to be active in cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Orthologous to human MAK (male germ cell associated kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 86.6) and Lung (RPKM 12.4) See more
    Orthologs
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    Genomic context

    See Mak in Genome Data Viewer
    Location:
    17p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (23889417..23936857)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23683753..23731125)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (21531651..21567742)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene synaptonemal complex protein 2-like Neighboring gene glial cells missing transcription factor 2 Neighboring gene uncharacterized LOC134482840 Neighboring gene transmembrane protein 14C Neighboring gene PAK1 interacting protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC93585

    Gene Ontology Provided by RGD

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables metal ion binding  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in chromatin remodeling  
    involved_in cilium assembly  
    involved_in intracellular signal transduction  
    involved_in intraciliary transport  
    involved_in negative regulation of non-motile cilium assembly  
    acts_upstream_of_or_within negative regulation of non-motile cilium assembly  
    involved_in non-motile cilium assembly  
    acts_upstream_of non-motile cilium assembly  
    involved_in photoreceptor cell maintenance  
    acts_upstream_of_or_within photoreceptor cell maintenance  
    involved_in photoreceptor cell maintenance  
    involved_in photoreceptor cell maintenance  
    involved_in positive regulation of DNA-templated transcription  
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in spermatogenesis  
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    located_in axoneme  
    located_in axoneme  
    located_in centrosome  
    located_in centrosome  
    located_in centrosome  
    is_active_in cilium  
    is_active_in cytoplasm  
    located_in midbody  
    located_in midbody  
    located_in midbody  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in motile cilium  
    located_in motile cilium  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in photoreceptor connecting cilium  
    located_in photoreceptor connecting cilium  
    located_in photoreceptor inner segment  
    located_in photoreceptor inner segment  
    located_in photoreceptor inner segment  
    located_in photoreceptor outer segment  
    located_in photoreceptor outer segment  
    located_in photoreceptor outer segment  
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    serine/threonine-protein kinase MAK
    NP_037268.2
    XP_038951317.1
    XP_038951319.1
    XP_038951321.1
    XP_038951322.1
    XP_038951323.1
    XP_038951324.1
    XP_063132181.1
    XP_063132182.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013136.3NP_037268.2  serine/threonine-protein kinase MAK

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      G3V7Y4, P20793, Q6AYW0
      UniProtKB/TrEMBL
      A0A8I6G9U0
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      23889417..23936857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276111.1XP_063132181.1  serine/threonine-protein kinase MAK isoform X2

      UniProtKB/TrEMBL
      A0A8I6G9U0
    2. XM_063276112.1XP_063132182.1  serine/threonine-protein kinase MAK isoform X4

      UniProtKB/TrEMBL
      A0A8I6AB71
    3. XM_039095389.2XP_038951317.1  serine/threonine-protein kinase MAK isoform X1

      UniProtKB/Swiss-Prot
      G3V7Y4, P20793, Q6AYW0
      UniProtKB/TrEMBL
      A0A8I6G9U0
      Related
      ENSRNOP00000020672.4, ENSRNOT00000020672.9
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    4. XM_039095395.2XP_038951323.1  serine/threonine-protein kinase MAK isoform X4

      UniProtKB/TrEMBL
      A0A8I6AB71
      Related
      ENSRNOP00000079083.1, ENSRNOT00000107200.2
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    5. XM_039095396.1XP_038951324.1  serine/threonine-protein kinase MAK isoform X5

      UniProtKB/TrEMBL
      A0A8I6G9U0
      Related
      ENSRNOP00000084056.2, ENSRNOT00000105813.2
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    6. XM_039095393.1XP_038951321.1  serine/threonine-protein kinase MAK isoform X2

      UniProtKB/TrEMBL
      A0A8I6G9U0
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    7. XM_039095391.2XP_038951319.1  serine/threonine-protein kinase MAK isoform X1

      UniProtKB/Swiss-Prot
      G3V7Y4, P20793, Q6AYW0
      UniProtKB/TrEMBL
      A0A8I6G9U0
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    8. XM_039095394.2XP_038951322.1  serine/threonine-protein kinase MAK isoform X3

      UniProtKB/TrEMBL
      A0A8I6G9U0
      Conserved Domains (1) summary
      cd07830
      Location:1250
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
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