U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Irf2bpl interferon regulatory factor 2 binding protein-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314329, updated on 9-Dec-2024

    Summary

    Official Symbol
    Irf2bplprovided by RGD
    Official Full Name
    interferon regulatory factor 2 binding protein-likeprovided by RGD
    Primary source
    RGD:1310994
    See related
    EnsemblRapid:ENSRNOG00000011026 AllianceGenome:RGD:1310994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eap1; Pqcp; RGD1310994
    Summary
    Predicted to enable transcription corepressor activity and ubiquitin protein ligase activity. Involved in development of secondary female sexual characteristics. Located in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures. Orthologous to human IRF2BPL (interferon regulatory factor 2 binding protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Irf2bpl in Genome Data Viewer
    Location:
    6q31
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112258149..112262264, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106527179..106531294, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (110901940..110904288, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479453 Neighboring gene uncharacterized LOC108351280 Neighboring gene uncharacterized LOC134479454 Neighboring gene uncharacterized LOC102555554 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding  
    enables transcription corepressor activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    probable E3 ubiquitin-protein ligase IRF2BPL
    Names
    enhanced at puberty protein 1
    polyglutamine-containing protein
    NP_001012488.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012470.2NP_001012488.2  probable E3 ubiquitin-protein ligase IRF2BPL

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q4G048, Q5EIC4
      UniProtKB/TrEMBL
      M0R567
      Related
      ENSRNOP00000064525.1, ENSRNOT00000014645.8
      Conserved Domains (2) summary
      cd16511
      Location:699754
      vRING-HC_IRF2BP1_like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins
      pfam11261
      Location:1061
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      112258149..112262264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.