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    Ppp4c protein phosphatase 4, catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171366, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppp4cprovided by RGD
    Official Full Name
    protein phosphatase 4, catalytic subunitprovided by RGD
    Primary source
    RGD:621225
    See related
    EnsemblRapid:ENSRNOG00000019813 AllianceGenome:RGD:621225
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ppx
    Summary
    Enables lamin binding activity and phosphatase activity. Involved in cellular response to interleukin-1; dephosphorylation; and negative regulation of protein phosphorylation. Located in nucleus. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 242.2), Spleen (RPKM 209.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ppp4c in Genome Data Viewer
    Location:
    1q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190823447..190830247, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181392899..181399703, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198219012..198225775, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene yippee-like 3 Neighboring gene T-box transcription factor 6 Neighboring gene uncharacterized LOC103691235 Neighboring gene aldolase, fructose-bisphosphate A Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC94490

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables histone H2AXS140 phosphatase activity  
    enables lamin binding PubMed 
    enables metal ion binding  
    enables myosin phosphatase activity  
    enables phosphatase activity PubMed 
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein-containing complex binding PubMed 
    Component Evidence Code Pubs
    located_in centrosome  
    located_in chromatin  
    located_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of protein phosphatase 4 complex  
    part_of protein phosphatase 4 complex  

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 4 catalytic subunit
    Names
    PP4C
    pp4
    protein phosphatase 4 (formerly X), catalytic subunit
    NP_599186.1
    XP_006230268.1
    XP_017444223.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134359.1NP_599186.1  serine/threonine-protein phosphatase 4 catalytic subunit

      See identical proteins and their annotated locations for NP_599186.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091574
      UniProtKB/Swiss-Prot
      Q5BJ92
      Conserved Domains (2) summary
      PTZ00239
      Location:6307
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:6290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190823447..190830247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230206.3XP_006230268.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

      See identical proteins and their annotated locations for XP_006230268.1

      UniProtKB/TrEMBL
      A6I9D8, G3V8M5
      Related
      ENSRNOP00000026909.4, ENSRNOT00000026909.9
      Conserved Domains (1) summary
      cd07415
      Location:6290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    2. XM_017588734.3XP_017444223.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X2

      Conserved Domains (1) summary
      cd07415
      Location:1211
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
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