Fgf13 fibroblast growth factor 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgf13provided by RGD
Official Full Name: fibroblast growth factor 13provided by RGD
Primary source: RGD:620164
See related: EnsemblRapid:ENSRNOG00000042753 AllianceGenome:RGD:620164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fgf1c; FGF-13
Summary: Predicted to enable sodium channel regulator activity; transmembrane transporter binding activity; and tubulin binding activity. Involved in response to odorant. Predicted to be located in several cellular components, including growth cone; intercalated disc; and lateral plasma membrane. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 90 and non-syndromic X-linked intellectual disability. Orthologous to human FGF13 (fibroblast growth factor 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 181.2), Heart (RPKM 90.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (142312381..142838581, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (137276498..137800056, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (142053648..142589274, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fibroblast growth factor homologous factors (FGF11-14) modulate cardiac calcium channels.
Title: Fibroblast growth factor homologous factors modulate cardiac calcium channels.
FHF2B is selectively localized at nodes of dorsal root sensory but not ventral root motor axons. This may provide a basis for physiological differences in Na currents that have been reported at the nodes of Ranvier in sensory versus motor axons.
Title: Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons.

Submit: New GeneRIF Correction

General gene information

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Markers

Fgf13 (e-PCR), detects polymorphism
- UniSTS:519416

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
NOT involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching morphogenesis of a nerve	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex cell migration	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex cell migration	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in establishment of neuroblast polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of neuroblast polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of neuroblast polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in inhibitory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in inhibitory synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in learning	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collateral sprouting	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of voltage-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of voltage-gated sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to odorant	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor 13

Names: fibroblast growth factor 1c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431643.1 → NP_001418572.1 fibroblast growth factor 13 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZYF4
NM_001431644.1 → NP_001418573.1 fibroblast growth factor 13 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZYF4
NM_001431645.1 → NP_001418574.1 fibroblast growth factor 13 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZYF4
NM_001431646.1 → NP_001418575.1 fibroblast growth factor 13 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZYF4
NM_001431647.1 → NP_001418576.1 fibroblast growth factor 13 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2JZ77
NM_001431648.1 → NP_001418577.1 fibroblast growth factor 13 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q9ERW3

UniProtKB/TrEMBL

A0A7U3L5J6
NM_053428.3 → NP_445880.1 fibroblast growth factor 13 isoform 4

See identical proteins and their annotated locations for NP_445880.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q9ERW3

Related

ENSRNOP00000062217.2, ENSRNOT00000064780.5

Conserved Domains (1) summary

smart00442
Location:14 → 144

FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

142312381..142838581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017602169.3 → XP_017457658.1 fibroblast growth factor 13 isoform X1

UniProtKB/TrEMBL

A0A8I5ZYF4

Conserved Domains (1) summary

smart00442
Location:77 → 207

FGF; Acidic and basic fibroblast growth factor family
XM_017602168.3 → XP_017457657.1 fibroblast growth factor 13 isoform X1

Conserved Domains (1) summary

smart00442
Location:77 → 207

FGF; Acidic and basic fibroblast growth factor family
XM_063280343.1 → XP_063136413.1 fibroblast growth factor 13 isoform X3
XM_063280342.1 → XP_063136412.1 fibroblast growth factor 13 isoform X1
XM_039100115.2 → XP_038956043.1 fibroblast growth factor 13 isoform X1

Conserved Domains (1) summary

smart00442
Location:77 → 207

FGF; Acidic and basic fibroblast growth factor family
XM_006257592.2 → XP_006257654.1 fibroblast growth factor 13 isoform X2

Related

ENSRNOP00000072195.1, ENSRNOT00000077402.3

Conserved Domains (1) summary

smart00442
Location:67 → 197

FGF; Acidic and basic fibroblast growth factor family