U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Epn1 Epsin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117277, updated on 9-Dec-2024

    Summary

    Official Symbol
    Epn1provided by RGD
    Official Full Name
    Epsin 1provided by RGD
    Primary source
    RGD:619772
    See related
    EnsemblRapid:ENSRNOG00000015753 AllianceGenome:RGD:619772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables clathrin adaptor activity and transmembrane transporter binding activity. Involved in several processes, including clathrin coat assembly; membrane fission; and positive regulation of clathrin coat assembly. Located in cytosol; postsynaptic membrane; and presynaptic membrane. Is active in Schaffer collateral - CA1 synapse and postsynapse. Biomarker of middle cerebral artery infarction. Orthologous to human EPN1 (epsin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 330.3), Heart (RPKM 299.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Epn1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (77771335..77789411, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (68742491..68760570, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72294153..72310217, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAS-like, family 2, locus 9 Neighboring gene ret finger protein-like 4A Neighboring gene U2 small nuclear RNA auxiliary factor 2 Neighboring gene coiled-coil domain containing 106

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity PubMed 
    enables clathrin binding  
    enables lipid binding  
    enables molecular sequestering activity  
    enables phospholipid binding  
    enables protein binding PubMed 
    enables transmembrane transporter binding PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    part_of clathrin vesicle coat  
    located_in clathrin-coated pit  
    located_in cytoplasm  
    located_in cytosol PubMed 
    is_active_in endosome  
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    is_active_in postsynapse PubMed 
    located_in postsynaptic membrane PubMed 
    located_in presynaptic membrane PubMed 
    located_in terminal bouton PubMed 

    General protein information

    Preferred Names
    epsin-1
    Names
    EPS-15-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057136.2NP_476477.1  epsin-1

      See identical proteins and their annotated locations for NP_476477.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88339
      UniProtKB/TrEMBL
      A0A140TAC3, A6KNR8
      Related
      ENSRNOP00000021286.4, ENSRNOT00000021286.7
      Conserved Domains (2) summary
      PRK07764
      Location:270437
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd16990
      Location:19142
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      77771335..77789411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.