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    Acadsb acyl-CoA dehydrogenase, short/branched chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25618, updated on 9-Dec-2024

    Summary

    Symbol
    Acadsbprovided by RGD
    Full Name
    acyl-CoA dehydrogenase, short/branched chainprovided by RGD
    Primary source
    RGD:2013
    See related
    EnsemblRapid:ENSRNOG00000020624 AllianceGenome:RGD:2013
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables electron transfer activity and short-chain fatty acyl-CoA dehydrogenase activity. Acts upstream of or within acyl-CoA metabolic process. Predicted to be located in membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 400.3), Kidney (RPKM 320.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Acadsb in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (195619088..195660564)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (186188939..186227796)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201981362..202022771)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphoseryl-tRNA kinase Neighboring gene IKAROS family zinc finger 5 Neighboring gene motile sperm domain containing 3, pseudogene 1 Neighboring gene uncharacterized LOC134483943

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within acyl-CoA metabolic process PubMed 
    involved_in carboxylic acid catabolic process  
    involved_in fatty acid beta-oxidation PubMed 
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process PubMed 
    involved_in isoleucine catabolic process  
    involved_in isoleucine catabolic process  
    involved_in isoleucine catabolic process  
    Component Evidence Code Pubs
    located_in membrane  
    located_in mitochondrial matrix  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    2-MEBCAD
    2-methyl branched chain acyl-CoA dehydrogenase
    2-methylbutyryl-CoA dehydrogenase
    2-methylbutyryl-coenzyme A dehydrogenase
    Acyl-Coenzyme A dehydrogenase short-branched chain
    SBCAD
    acyl-Coenzyme A dehydrogenase, short/branched chain
    NP_037216.1
    XP_008758088.1
    XP_063138171.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013084.2NP_037216.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_037216.1

      Status: PROVISIONAL

      Source sequence(s)
      U64451
      UniProtKB/Swiss-Prot
      P70584
      UniProtKB/TrEMBL
      A0A8I6GLN2, A6HWW9
      Related
      ENSRNOP00000096562.2, ENSRNOT00000101166.2
      Conserved Domains (2) summary
      cd01158
      Location:59430
      SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
      COG1960
      Location:57428
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      195619088..195660564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282101.1XP_063138171.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6G5Q8
    2. XM_008759866.4XP_008758088.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I6G5Q8
      Related
      ENSRNOP00000092354.2, ENSRNOT00000112423.2
      Conserved Domains (2) summary
      cd01158
      Location:59409
      SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
      COG1960
      Location:57409
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
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