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    Rhd Rh blood group, D antigen [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rhdprovided by RGD
    Official Full Name
    Rh blood group, D antigenprovided by RGD
    Primary source
    RGD:620451
    See related
    EnsemblRapid:ENSRNOG00000017130 AllianceGenome:RGD:620451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rh; Rhced
    Summary
    Predicted to enable ammonium channel activity. Predicted to be involved in ammonium homeostasis and ammonium transmembrane transport. Predicted to act upstream of or within erythrocyte development and multicellular organismal-level iron ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Rh isoimmunization. Orthologous to several human genes including RHD (Rh blood group D antigen). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 483.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhd in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (152371160..152405396)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (147087479..147121716)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (153197416..153232009)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A, pseudogene 9 Neighboring gene macoilin 1 Neighboring gene uncharacterized LOC134487008 Neighboring gene transmembrane protein 50A Neighboring gene arginine and serine rich protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mouse Rh blood group gene. Westhoff CM, et al. Genomics, 1999 May 1. PMID 10329015
    2. Generation and characterisation of Rhd and Rhag null mice. Goossens D, et al. Br J Haematol, 2010 Jan. PMID 19807729
    3. Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene. Kitano T, et al. Biochem Biophys Res Commun, 1998 Aug 10. PMID 9705835
    4. Evolutionary conservation and diversification of Rh family genes and proteins. Huang CH, et al. Proc Natl Acad Sci U S A, 2005 Oct 25. PMID 16227429, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ammonium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ammonium homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ammonium transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ammonium transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    blood group Rh(D) polypeptide
    Names
    Rhesus blood group CE and D
    erythrocyte membrane glycoprotein Rh30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429898.1 → NP_001416827.1  blood group Rh(D) polypeptide isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IT38

    2. NM_022505.3 → NP_071950.1  blood group Rh(D) polypeptide isoform 1

      See identical proteins and their annotated locations for NP_071950.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      O88298
      UniProtKB/TrEMBL
      A6IT38
      Related
      ENSRNOP00000023187.4, ENSRNOT00000023187.7
      Conserved Domains (1) summary
      cl03012
      Location:46 → 397
      Ammonium_transp; Ammonium Transporter Family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      152371160..152405396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239268.4 → XP_006239330.1  blood group Rh(D) polypeptide isoform X1

      Conserved Domains (1) summary
      cl03012
      Location:46 → 275
      Ammonium_transp; Ammonium Transporter Family

    2. XM_039110697.2 → XP_038966625.1  blood group Rh(D) polypeptide isoform X2

      Conserved Domains (1) summary
      cl03012
      Location:49 → 226
      Ammonium_transp; Ammonium Transporter Family

    RNA

    1. XR_010066465.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88298.1 GenPept UniProtKB/Swiss-Prot:O88298

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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