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    Edem1 ER degradation enhancing alpha-mannosidase like protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297504, updated on 9-Dec-2024

    Summary

    Official Symbol
    Edem1provided by RGD
    Official Full Name
    ER degradation enhancing alpha-mannosidase like protein 1provided by RGD
    Primary source
    RGD:1563633
    See related
    EnsemblRapid:ENSRNOG00000055365 AllianceGenome:RGD:1563633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563633
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Predicted to be involved in several processes, including positive regulation of retrograde protein transport, ER to cytosol; proteolysis involved in protein catabolic process; and trimming of terminal mannose on C branch. Predicted to act upstream of or within ERAD pathway. Predicted to be located in aggresome; endoplasmic reticulum membrane; and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 531.1), Lung (RPKM 308.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Edem1 in Genome Data Viewer
    Location:
    4q41
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (143350989..143385693)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (141797631..141829717)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (140886644..140918654)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102361 Neighboring gene ARF like GTPase 8B Neighboring gene uncharacterized LOC108350874 Neighboring gene proteasome 26S subunit, ATPase 4, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in aggresome  
    located_in aggresome  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum quality control compartment  

    General protein information

    Preferred Names
    ER degradation-enhancing alpha-mannosidase-like protein 1
    Names
    ER degradation enhancer, mannosidase alpha-like 1
    ER degradation-enhancing alpha-mannosidase-like 1
    NP_001292208.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305279.1 → NP_001292208.1  ER degradation-enhancing alpha-mannosidase-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D3ZJE0
      Related
      ENSRNOP00000069931.1, ENSRNOT00000088273.3
      Conserved Domains (1) summary
      pfam01532
      Location:130 → 575
      Glyco_hydro_47; Glycosyl hydrolase family 47

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      143350989..143385693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_010065628.1 RNA Sequence

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